Connect with us

Health

WHO launches clinical trial for new Ebola treatment in DR Congo

info

Published

on

WHOGeneva008 1.jpg

MTN ADVERT

The World Health Organisation (WHO) has launched an international clinical trial in the Democratic Republic of the Congo (DRC) to evaluate two experimental treatments for Bundibugyo virus disease (BVD), a rare form of Ebola, as the country battles an ongoing outbreak.

The trial, known as the Platform Adaptive Randomised Trial for New and Repurposed Filovirus TreatmentS (PARTNERS), began enrolling patients on Thursday, WHO said in a statement.

The study will assess whether the monoclonal antibody MBP134 and the antiviral drug remdesivir can reduce deaths among people infected with the Bundibugyo virus. Researchers will also investigate whether combining the two medicines provides better outcomes than using either treatment alone.

The trial is sponsored by WHO and coordinated by the Institut National pour la Recherche Biomédicale (INRB) in the DRC, the Institute of Tropical Medicine in Belgium and the University of Oxford in the United Kingdom. It is supported by the Africa Centres for Disease Control and Prevention (Africa CDC) and other international research and humanitarian partners.

Search for effective treatment

The trial comes as the DRC continues to battle a Bundibugyo virus outbreak that has infected more than 1,400 people and claimed 440 lives, highlighting the urgent need for effective treatment.

PT WHATSAPP CHANNEL

WHO said there are currently no approved medicines specifically for Bundibugyo virus disease, although treatments exist for some other Ebola virus species.

“The trial comes as the DRC continues to grapple with a Bundibugyo virus outbreak that has infected more than 1,400 people. Nearly 210 patients have recovered, while about 440 people have died, underscoring the urgent need for effective treatment options.”

According to the organisation, the WHO Technical Advisory Group selected MBP134 and remdesivir after reviewing available scientific evidence, including laboratory findings, safety data and lessons from previous Ebola outbreaks.

Participants in the study will be monitored for at least 28 days after enrolment while receiving supportive care, including fluid replacement, oxygen therapy, blood pressure management and pain relief in line with WHO treatment guidelines.

WHO Director-General, Tedros  Ghebreyesus, said the trial offers hope to patients and affected communities.

“The PARTNERS trial, established with national authorities and scientific partners in record time, offers real hope that we can deliver concrete results for and with the communities at the heart of the outbreak.”

He noted that while some patients recover without specific treatment, effective medicines could significantly improve survival.

Why the trial matters

WHO said the adaptive design of the study allows researchers to add and evaluate new treatments as scientific evidence emerges, enabling a faster response during disease outbreaks.

Amanda Rojek, PARTNERS Trial Operations Lead at the Pandemic Sciences Institute, University of Oxford, said one of the major lessons from previous Ebola outbreaks was that research should be conducted alongside emergency response efforts rather than after outbreaks have ended.

She said the study could generate evidence quickly enough to guide treatment decisions during the current outbreak, potentially producing results within months.

The Director-General of the Institut National pour la Recherche Biomédicale, Jean-Jacques Muyembe-Tamfum, said integrating the trial into routine patient care would allow patients to access promising investigational therapies while helping scientists improve responses to future outbreaks.

READ ALSO: WHO declares international Hantavirus outbreak over

“By integrating this trial into clinical care, we are giving patients access to promising investigational treatments while generating the evidence needed to improve care for current and future outbreaks,” he said.

The DRC’s Health Minister, Samuel Kamba, described the launch of the PARTNERS trial as a major milestone for the country’s public health response, expressing optimism that it could identify more effective treatments, save lives during the current outbreak and strengthen global preparedness for future Ebola outbreaks.

Ebola

Bundibugyo virus disease is one of the six known species of the Ebola virus. It was first identified in Uganda in 2007 and causes symptoms similar to other forms of Ebola, including fever, severe weakness, vomiting, diarrhoea and, in severe cases, internal and external bleeding.

Unlike the Zaire strain of Ebola, for which licensed vaccines and treatments exist, there are currently no approved vaccines or medicines specifically targeting the Bundibugyo virus.


Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Health

Plateau records 11,000 TB cases in 2026, 2,047 detected in three months

info

Published

on

PlateauStatemap 1000x600 2.png

Plateau State has an estimated 11,000 tuberculosis (TB) cases in 2026, with 2,047 patients identified between July and September, according to a state health official.

The cases were disclosed by Yohanna Bot, the monitoring and evaluation officer of the Plateau State Tuberculosis and Leprosy Control Programme, at a media advocacy meeting on community-led monitoring of health services in Jos.

Mr Bot said the estimated burden was based on a TB prevalence rate of 219 cases per 100,000 people, warning that the disease remained a major public health challenge in the state.

“From our quarterly survey, we discovered that between July and September, 2,047 patients were identified and placed on treatment,” he said.

He added that the identified patients were receiving treatment at health facilities across the state.

Tuberculosis is an infectious disease that primarily affects the lungs and spreads through the air when an infected person coughs, sneezes or speaks.

PT WHATSAPP CHANNEL
Dangote Refinery AD

Mr Bot identified malnutrition, advanced age, weakened immunity, overcrowding and HIV infection as factors that could increase the risk of contracting the disease or developing severe illness.

He also expressed concern over stigma and misconceptions surrounding TB, saying some residents attributed the disease to spiritual or ritual causes rather than seeking medical attention.

According to him, such beliefs discourage people from undergoing early diagnosis and starting treatment promptly.

Insecurity, displacement worsen TB risks

Mr Bot said insecurity and displacement were complicating efforts to detect and manage tuberculosis, particularly in Mangu, Jos South and Barkin Ladi local government areas.

He said displacement had led to the establishment of camps for internally displaced persons (IDPs), where overcrowded living conditions could facilitate the spread of the disease.

To address the challenge, he said the state programme was prioritising community outreach and active screening in IDP camps and correctional centres to identify people with TB and link them to treatment.

Mr Bot said patients who received effective treatment could become much less infectious after starting therapy, although the timing depended on their clinical condition and response to treatment.

He, however, raised concerns about shortages of anti-TB medicines, attributing the gaps in availability partly to disruptions in the supply chain and the programme’s dependence on international support, particularly funding from the Global Fund.

He called for increased public awareness to address stigma and misconceptions and urged residents with symptoms suggestive of TB to seek medical evaluation at health facilities.

Community monitoring targets healthcare gaps

Peter Ezekiel, the Plateau State programme officer of the Global Fund AIDS, Tuberculosis and Malaria Integrated Community-Led Monitoring Project, said Nigeria continued to face a significant burden of tuberculosis, HIV and malaria.

He said community-led monitoring was designed to involve residents and other stakeholders in identifying gaps in healthcare delivery and supporting interventions to improve access to essential services.

According to him, the approach helps communities identify barriers such as discrimination, stigma and gender-related challenges while advocating better infrastructure and increased domestic funding for healthcare.

Mr Ezekiel said the initiative had supported infrastructure rehabilitation, service improvements and stronger community participation in Plateau State.

He listed the rehabilitation and re-piping of toilet facilities at the Primary Health Centre in Rantya, Jos South, among the interventions carried out since June.

He said community stakeholders had also donated a scanning machine and 10 iron-framed chairs to the Primary Health Centre in Gangare, Jos North, as well as a blood pressure monitoring device to the facility in Dogon Agogo.

Other interventions included the provision of hospital bed mattresses to the Primary Health Centre in Pushit, Mangu, and tuberculosis sputum collection cups to the COCIN Rehabilitation Centre in Mangu.

Mr Ezekiel said community members had also provided 500 copies of patient enrolment forms to support healthcare delivery.

In Lamingo, he said residents mobilised resources to engage security personnel to protect night-shift workers and property at the local primary healthcare centre, with an agreed monthly payment of N15,000.

He said the interventions had improved infection prevention, patients’ experiences and healthcare delivery.

Mr Ezekiel called for stronger collaboration among communities, government agencies and health partners, alongside adequate funding for primary healthcare and greater accountability in the management of health resources.

READ ALSO: PT Health Watch: What you should know about Tuberculosis, why it persists

He also urged the expansion of national and state health insurance programmes to cover vulnerable people, particularly low-income earners.

Official highlights role of community monitoring

Yakubu Izang, the director of disease control and immunisation at the Plateau State Primary Health Care Board, said community-led monitoring was important for identifying healthcare delivery problems that might otherwise go unnoticed by government agencies.

He said the approach enabled communities and public officials to work together to identify challenges and develop solutions to improve access to healthcare services.


Discover more from Premium Times Nigeria

Subscribe to get the latest posts sent to your email.

Continue Reading

Health

Katsina health workers suspend strike

info

Published

on

Bad75a1d 1d69 4d2c b4da 731ab4e9cdde 1 e1766229094423.jpeg

Health workers in Katsina State have suspended their seven-day warning strike following talks with Governor Dikko Radda over outstanding salary adjustments and welfare demands.

The suspension took effect on Sunday, 18 October, according to a circular reportedly issued by the Assembly of Healthcare Professionals (AHCP).

The development was announced in a newsflash attributed to the governor’s Chief Press Secretary, Ibrahim Mohammed, and also reported by Katsina Times.

The circular, dated 17 October and attributed to the assembly’s chairman, Ibrahim Balange, directed members to resume clinical and administrative duties across public health facilities following a meeting with the governor on 16 October.

The assembly comprises the Medical and Health Workers Union of Nigeria (MHWUN), the National Association of Nigerian Nurses and Midwives (NANNM), and the National Union of Allied Health Professionals (NUAHP).

According to the statement, the governor committed to reopening negotiations over the workers’ outstanding demands, including salary adjustments, allowances and career progression.

PT WHATSAPP CHANNEL
Dangote Refinery AD

However, the announcement did not establish whether the government had agreed to the workers’ proposed salary adjustments or when outstanding payments would be made.

Government’s commitments

The statement attributed to Mr Kaula said the government agreed to reopen negotiations through a technical roundtable.

The commitments include a review and implementation of the Consolidated Health Salary Structure (CONHESS) in accordance with applicable government circulars, alongside a comprehensive review of hazard, call duty and shift duty allowances.

The government also reportedly agreed to address the skipping of CONHESS grade level 10 for eligible officers, in line with the applicable scheme of service.

A joint technical committee is expected to be established with defined terms of reference and a timeline for addressing the outstanding issues.

However, neither the statement nor the reported circular specified when the committee would begin work or when the proposed adjustments would be implemented.

The assembly reportedly commended Mr Radda for intervening in the dispute and thanked its members for their cooperation during the industrial action.

How the dispute began

The suspension follows months of disagreement between health workers and the Katsina State Government over salary disparities and allowances.

As PREMIUM TIMES reported on 15 October, the assembly declared the warning strike after a seven-day notice issued on 7 October expired without a satisfactory resolution.

Mr Balange said the dispute dated back to 2024, when the government indicated plans to review health workers’ remuneration in line with what their counterparts receive in federal health institutions.

A committee established to examine the complaints subsequently submitted recommendations in March 2025, but the union said the government failed to implement them.

According to the union, the state’s Office of Public Service Reform initially offered workers 10 per cent of the salary difference between state and federal health professionals.

The government later increased the offer to 15 per cent, but the workers rejected it as inadequate.

Mr Balange said the assembly had sought full implementation of the applicable federal salary structure and allowances but was willing to accept 75 per cent as a compromise.

The disagreement eventually led to the warning strike, which began on 14 October.

Patients affected by strike

The industrial action disrupted services at public hospitals, leaving patients and caregivers uncertain about access to treatment.

A PREMIUM TIMES report published on Sunday documented disruptions at Turai Yar’Adua Maternal and Child Hospital in Katsina.

During a visit to the hospital on Saturday, only a few patients were seen around the surgical ward.

Caregivers expressed concern over the disruption, including difficulties accessing treatment for patients requiring medical attention.

The state Head of Service, Masa’ud Banye, had confirmed that government officials were engaging the unions to resolve the disagreement.

Although the assembly has now directed its members to return to work, the extent to which normal services have resumed across affected hospitals has not been independently established.

What remains unresolved

The suspension ends the immediate industrial action but leaves questions about the implementation of the government’s commitments.

The reported agreement does not clarify whether the government has withdrawn its earlier 15 per cent offer, accepted the union’s proposed 75 per cent compromise or agreed to another salary adjustment.

It also provides no specific date for settling outstanding allowances or completing negotiations.

The workers are seeking improved remuneration and allowances comparable to those available to their counterparts in federal health institutions.

For now, the reported agreement provides a basis for renewed negotiations, while the resolution of the underlying dispute depends on whether the government and unions reach an implementable settlement.


Discover more from Premium Times Nigeria

Subscribe to get the latest posts sent to your email.

Continue Reading

Trending