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WHO recommends a clinical trial of Ebola vaccine against Bundibugyo virus

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The World Health Organisation (WHO) has recommended that a vaccine called Ervebo be prioritised for a randomised clinical trial against Bundibugyo virus disease in the Democratic Republic of Congo (DRC).
The recommendation followed preliminary animal study data suggesting that the vaccine may provide some cross-protection against the disease, particularly in reducing deaths.

WHO’s Technical Advisory Group on Candidate Vaccine Prioritisation made the recommendation at its third meeting on 31 July, after reviewing available evidence on the vaccine’s safety, efficacy, availability and feasibility.

The development comes as the DRC continues to respond to an outbreak of Ebola disease caused by the Bundibugyo virus, which was declared on 15 May 2026.

As of 30 July, WHO had recorded 3,605 confirmed cases and 1,587 deaths from the outbreak in the DRC.

Why Ervebo is being considered

The advisory group’s recommendation is significant because Ervebo was developed specifically against Ebola virus disease caused by the Ebola Zaire virus, rather than the Bundibugyo virus.

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According to WHO, the group initially advised against using Ervebo outside carefully designed research settings because its effectiveness against Bundibugyo virus disease remained uncertain.

However, preliminary animal study data indicate that Ervebo may confer some cross-protection against Bundibugyo virus disease, particularly by reducing mortality.

The latest evidence prompted the advisory group to recommend that Ervebo be prioritised for a randomised clinical trial to determine its effectiveness against the disease.

What is the Bundibugyo virus?

The Bundibugyo virus causes Ebola disease. It is distinct from the Ebola virus that Ervebo was specifically developed to protect against.

The Bundibugyo virus disease outbreak in the DRC is the first of its kind in the country. WHO says there is currently no licensed vaccine or specific treatment for Bundibugyo virus disease.

The disease is a severe infection, and previous Bundibugyo virus disease outbreaks have recorded case fatality rates ranging from 30 to 50 per cent, according to WHO.

Safety concerns

According to WHO, the advisory group found no identified safety concerns with the use of Ervebo among contacts of confirmed cases during a Bundibugyo virus disease outbreak.

READ ALSO: WHO raises alarm as DR Congo’s Ebola outbreak surpasses 3,600 cases

However, the experts stressed that the vaccine’s effectiveness against Bundibugyo virus disease and its ability to prevent transmission have not been established.

They therefore recommended that these questions be evaluated through clinical research.

WHO said a vaccine specifically developed against the Bundibugyo virus would remain the preferred option, although preliminary data on such candidates are currently unavailable.

The advisory group also emphasised the need to facilitate large-scale vaccine production and access if future evidence demonstrates sufficient efficacy to protect affected populations.


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Health

Six climate measures could save 1.6 million lives yearly – WHO

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Six proven climate and health interventions could prevent 1.6 million deaths annually and generate trillions of dollars in economic benefits if implemented globally, the World Health Organisation (WHO) has revealed.

The measures, which include heat-health warning systems, access to safe water and sanitation, cleaner household energy and more efficient fossil fuel pricing policies, could generate $3.9 trillion in annual economic welfare benefits and a further $5.4 trillion in fiscal gains.

The WHO disclosed this in a new report titled ‘Global benefits and costs of prioritised actions on climate change and health’, released ahead of the 31st United Nations Climate Change Conference (COP31), where countries are expected to present their climate commitments.

According to the report, the six interventions could prevent one in every 40 deaths globally, based on modelled projections, while avoiding 16.7 billion tonnes of carbon dioxide emissions annually.

The estimated emissions reduction is equivalent to 31 per cent of global annual greenhouse gas emissions, excluding emissions from land use, land-use change and forestry.

The report, which the WHO described as its first comprehensive assessment of the economic and fiscal returns from scaling up the six recommended interventions, highlights the potential health and financial gains of integrating public health considerations into climate policies.

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It argues that many health consequences of climate change are preventable through existing solutions, but governments must implement them across health and other sectors that determine people’s health.

Six interventions

The report identifies six interventions: heat-health warning systems, climate-resilient drinking-water services, basic sanitation services, hygiene and handwashing facilities, cleaner household fuels and technologies for cooking and heating, and efficient fossil fuel pricing policies.

The WHO estimates that five of the interventions could generate $24 in benefits for every $1 invested, with returns expected to be greater in low- and middle-income countries.

Heat-health warning systems are projected to deliver particularly high returns, generating an estimated $835 in benefits for every $1 invested.

The report attributes the high returns to the relatively low cost of expanding existing warning systems and their potential to prevent heat-related illnesses.

Efficient fossil fuel pricing policies, however, are projected to deliver the largest overall gains.

Such policies, including removing inefficient fossil fuel subsidies and appropriately taxing fossil fuels, could prevent 1.2 million deaths annually while generating $3 trillion in economic welfare benefits and $5.4 trillion in fiscal gains.

Health at the centre of climate action

Commenting on the findings, WHO Director-General Tedros Ghebreyesus said the climate crisis was also a health crisis, but many of its consequences could be prevented using existing interventions.

READ ALSO: WHO raises alarm as 75% of diabetes cases in Africa remain undiagnosed

He said expanding proven and affordable interventions could save millions of lives, particularly in countries with the greatest need.

“The climate crisis is a health crisis, but much of the harm it causes can be prevented with tools we already have,” he said.

Mr Ghebreyesus urged governments to place health considerations at the centre of climate action as they prepare for the next round of international climate negotiations.

The WHO said countries were already experiencing record-breaking climate shocks in 2026, investing in measures that protect human health and the environment increasingly urgent.

The health body called on governments, development partners and financing institutions to use the economic evidence to scale up the interventions, noting that they could deliver simultaneous benefits for public health, climate mitigation and national economies.


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Health

FG targets 25,000 cataract surgeries, five million spectacles by 2027

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Nigeria has pledged to provide five million pairs of reading spectacles and 25,000 fully subsidised cataract surgeries by 2027 as part of efforts to expand access to eye care services nationwide.

The Minister of State for Health and Social Welfare, Iziaq Salako, announced the commitments at the Global Summit for Eye Health held in St John’s, Antigua and Barbuda, on 2 November.

Mr Salako, who delivered the closing address at the summit, said the federal government would also train 15,000 primary healthcare workers and integrate primary eye care services into the Basic Health Care Provision Fund (BHCPF).

He said the commitments formed part of Nigeria’s efforts to eliminate avoidable vision loss and expand access to quality eye care, particularly among vulnerable populations.

According to him, the government is targeting more than 25 million vulnerable Nigerians, especially women, older people and residents of underserved rural communities.

Nigeria’s eye health targets

Mr Salako said Nigeria would also work to increase its active eye care workforce by 20 per cent and raise its national Effective Cataract Surgical Coverage (eCSC) by 30 percentage points by 2030.

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He said the government would mobilise domestic public and private sector resources and collaborate with Commonwealth and international partners to ensure the commitments translate into measurable progress.

Mr Salako said Nigeria’s approach would build on the Effective Spectacle Coverage Initiative Nigeria, also known as JigiBola 2.0, which draws inspiration from the JigiBola programme introduced in Lagos State about 25 years ago.

He recalled volunteering as a young medical officer during the original programme, which provided free eye screening, spectacles and cataract surgeries.

Mr Salako said the initiative was now being expanded through a national programme to improve access to eye care.

Elimination of cataract blindness

Mr Salako said one of the major outcomes of the summit was a commitment to eliminate cataract-related blindness through the World Health Organisation’s (WHO) Global Cataract Surgery Initiative, known as SEE 2045.

He said Nigeria was among the beneficiary countries under the initiative, alongside Antigua and Barbuda, Bangladesh, Tanzania and China.

According to him, the initiative makes cataract elimination the second global elimination target for a non-communicable disease in WHO history.

He urged participating countries to demonstrate that expanding access to quality cataract surgery, including in rural communities, was achievable.

Mr Salako also called for proper documentation of successes and outcomes to enable countries to share implementation strategies and address the backlog of cataract surgeries.

He said avoidable vision loss had consequences beyond individual health, affecting education, household income, road safety and national productivity.

“When a child cannot see the chalkboard, or an artisan or farmer is blinded by cataracts or uncorrected refractive errors, an entire community pays the price,” he said.

Global partnerships

Mr Salako said the summit secured $60 million in philanthropic commitments to support assistive technology, alongside 15 private-sector commitments valued at more than $468 million to accelerate eye care implementation.

READ ALSO: Nigeria needs N104bn yearly for health security plan – NCDC

He added that organisations had made about 143 other commitments beyond those made by governments.

Mr Salako said the commitments demonstrated the importance of partnerships between governments, the private sector, philanthropic organisations and international development partners in improving global eye health.

He called on participating countries to sustain the momentum generated at the summit and ensure that the commitments translated into tangible improvements for people living with avoidable vision loss.

“Let us return to our respective nations as champions of sight, holding ourselves accountable to the millions who are waiting not for miracles, but for a pair of glasses, a timely referral, or a fifteen-minute surgical intervention that can restore their world,” he said.


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