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WHO recommends a clinical trial of Ebola vaccine against Bundibugyo virus

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The World Health Organisation (WHO) has recommended that a vaccine called Ervebo be prioritised for a randomised clinical trial against Bundibugyo virus disease in the Democratic Republic of Congo (DRC).
The recommendation followed preliminary animal study data suggesting that the vaccine may provide some cross-protection against the disease, particularly in reducing deaths.

WHO’s Technical Advisory Group on Candidate Vaccine Prioritisation made the recommendation at its third meeting on 31 July, after reviewing available evidence on the vaccine’s safety, efficacy, availability and feasibility.

The development comes as the DRC continues to respond to an outbreak of Ebola disease caused by the Bundibugyo virus, which was declared on 15 May 2026.

As of 30 July, WHO had recorded 3,605 confirmed cases and 1,587 deaths from the outbreak in the DRC.

Why Ervebo is being considered

The advisory group’s recommendation is significant because Ervebo was developed specifically against Ebola virus disease caused by the Ebola Zaire virus, rather than the Bundibugyo virus.

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According to WHO, the group initially advised against using Ervebo outside carefully designed research settings because its effectiveness against Bundibugyo virus disease remained uncertain.

However, preliminary animal study data indicate that Ervebo may confer some cross-protection against Bundibugyo virus disease, particularly by reducing mortality.

The latest evidence prompted the advisory group to recommend that Ervebo be prioritised for a randomised clinical trial to determine its effectiveness against the disease.

What is the Bundibugyo virus?

The Bundibugyo virus causes Ebola disease. It is distinct from the Ebola virus that Ervebo was specifically developed to protect against.

The Bundibugyo virus disease outbreak in the DRC is the first of its kind in the country. WHO says there is currently no licensed vaccine or specific treatment for Bundibugyo virus disease.

The disease is a severe infection, and previous Bundibugyo virus disease outbreaks have recorded case fatality rates ranging from 30 to 50 per cent, according to WHO.

Safety concerns

According to WHO, the advisory group found no identified safety concerns with the use of Ervebo among contacts of confirmed cases during a Bundibugyo virus disease outbreak.

READ ALSO: WHO raises alarm as DR Congo’s Ebola outbreak surpasses 3,600 cases

However, the experts stressed that the vaccine’s effectiveness against Bundibugyo virus disease and its ability to prevent transmission have not been established.

They therefore recommended that these questions be evaluated through clinical research.

WHO said a vaccine specifically developed against the Bundibugyo virus would remain the preferred option, although preliminary data on such candidates are currently unavailable.

The advisory group also emphasised the need to facilitate large-scale vaccine production and access if future evidence demonstrates sufficient efficacy to protect affected populations.


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Health

WHO warns immunisation gaps leave Nigerian children vulnerable to disease

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The World Health Organisation (WHO) has warned that gaps in routine immunisation are leaving Nigerian children vulnerable to preventable diseases, urging the government to increase domestic health financing and strengthen disease surveillance and outbreak preparedness.

Pavel Ursu, the WHO representative in Nigeria, raised the concern on Tuesday during the organisation’s Health Diplomacy Dialogue in Abuja, which brought together diplomats and health officials to discuss health security, disease outbreaks, global health financing and antimicrobial resistance.

Mr Ursu said Nigeria continued to face challenges in containing vaccine-preventable diseases, including measles and circulating vaccine-derived poliovirus, despite support from international partners.

He said the country’s immunisation programme must reach approximately eight million additional children annually, placing increasing pressure on the health system.

“If we want to maintain the same level of performance, we have to invest more,” he said.

Mr Ursu acknowledged support from Gavi, the Vaccine Alliance, and other partners in providing vaccines and related commodities but stressed the need for Nigeria to progressively increase domestic financing and assume greater responsibility for protecting its population.

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He also highlighted changes in global health cooperation, including declining development assistance for health and ongoing discussions about reforming the global health architecture.

He said African countries needed to strengthen domestic financing, improve health system resilience, expand digital health services and promote local manufacturing of health commodities.

Mr Ursu said the dialogue was established to provide a platform for the WHO and diplomatic missions to exchange strategic information on public health developments, emerging threats and international health policy, including for embassies without dedicated development cooperation programmes.

He called for stronger international cooperation, including timely information-sharing and coordinated responses to outbreaks that could cross national borders.

Outbreaks expose gaps in health security

Speaking on health security, Alex Chimbaru, the WHO emergencies adviser, said Nigeria’s disease outbreaks reflected persistent weaknesses in immunisation coverage, disease surveillance and access to safe water and sanitation.

He said more than 700 children had been disabled by circulating vaccine-derived poliovirus in previous years, warning that the actual number could be higher.

Mr Chimbaru also highlighted cholera as a major public health concern, citing inadequate water, sanitation and hygiene infrastructure, insecurity and population displacement as factors complicating prevention and response efforts.

He said Borno State accounted for 96 per cent of cases in the affected area discussed during his presentation, highlighting the need to prioritise interventions in vulnerable communities.

According to him, the WHO, other United Nations agencies, Médecins Sans Frontières (MSF) and other partners supported the response through surveillance, logistics, case management, vaccination, risk communication and infection prevention and control.

Mr Chimbaru called for sustained investment in water and sanitation, functional public health emergency operations centres, rapid response teams and stronger cross-border coordination to prevent and contain outbreaks.

He also urged development partners to reinforce government-led health systems rather than establish parallel structures, stressing that sustainable financing and stronger primary healthcare services were essential to health security.

Abuja to host global conference on antimicrobial resistance

The dialogue also featured discussions on Nigeria’s preparations to host a global conference on antimicrobial resistance (AMR) in Abuja from 6 to 8 December.

Mary Bartuo, the WHO team lead for universal health coverage and life course, said the conference would seek to translate international commitments into measurable action, stronger accountability and sustainable financing.

READ ALSO: Non-communicable diseases caused 74% of global deaths in 2023 – WHO

She said AMR was associated with about one million deaths annually in the African Region and posed growing threats to food security, livestock production and economic development.

Ms Bartuo said priorities under the proposed Abuja Compact included responsible AMR use, infection prevention and control, vaccination, water and sanitation, equitable access to medicines and diagnostics, research, local manufacturing and sustainable financing.

She urged diplomatic missions to participate in the conference and support efforts to strengthen national and international responses to AMR.

The WHO officials called for sustained investment and stronger collaboration among governments, diplomatic missions and development partners to improve health security and strengthen countries’ capacity to prevent, detect and respond to public health threats.


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Health

AMR: Livestock uses more antibiotics than human health sector

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The Coordinating Minister of Health and Social Welfare, Muhammad Pate, has said the livestock sector uses more antibiotics than the human health sector.

Mr Pate noted that the responsible use of the drugs in livestock could help reduce the pressure driving antimicrobial resistance (AMR) that can affect humans.

He made the statement on Monday in Abuja at a joint One Health ministerial briefing ahead of the fifth Global High-Level Ministerial Conference on AMR.

Explaining the need for a multi-sectoral approach to AMR, the minister said antimicrobial use in livestock is an important part of the resistance problem.

“The livestock sector uses more antibiotics than the human health sector. So if they are used better, then there’s less pressure for antimicrobial resistance to develop that can affect people,” he said.

Mr Pate said antimicrobial resistance could move between humans, animals and the environment, emphasising the need for collaboration across sectors.

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“Much of the zoonotic disease and AMR can come from animal health to humans,” he said, adding that the use of antimicrobials in animal health and human health could have consequences for the wider population.

Prevention before treatment

The minister said efforts to control AMR should not focus only on the treatment of infections but also on preventing diseases that require antimicrobial medicines.

He identified vaccination, hygiene, biosecurity, infection prevention and control, and improved diagnostics as important measures.

“If you can prevent the disease, then you don’t need to use the antimicrobial,” Mr Pate said.

He also urged Nigerians to avoid using antibiotics unnecessarily, noting that not every cough or catarrh requires antibiotic treatment.

“It’s not every cough that needs to use antibiotics. It’s not every catarrh that needs to use antibiotics, please consult a doctor,” he said.

Livestock practices

The Minister of State for Agriculture and Food Security, Aliyu Abdullahi, said AMR also poses a threat to agriculture and food security.

Mr Abdullahi said inappropriate or excessive use of antimicrobials and agrochemicals could undermine disease control, food safety, trade and livelihoods.

According to him, the agriculture sector is prioritising responsible use of antimicrobials, farmer education, extension services, good agricultural practices and biosecurity.

One Health approach

The Minister of Environment, Balarabe Lawal, said AMR cuts across human, animal and environmental health.

READ ALSO: CSOs demand disclosure of JBS $2.5bn Nigeria deal, warn of livestock expansion risks

“Resistance does not respect boundaries. It cuts across sectors. It moves from people to animals, from farms to food, and through water, soil, and waste systems,” Mr Lawal said.

The ministers’ meeting is part of preparations for the fifth Global High-Level Ministerial Conference on AMR, which will be held in Abuja from 6 to 8 December.

The conference is the first global high-level ministerial conference on AMR to be held in Africa, with the theme, “One Healthcare: Advancing global AMR commitments to local action.”


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