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WHO recommends a clinical trial of Ebola vaccine against Bundibugyo virus

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The World Health Organisation (WHO) has recommended that a vaccine called Ervebo be prioritised for a randomised clinical trial against Bundibugyo virus disease in the Democratic Republic of Congo (DRC).
The recommendation followed preliminary animal study data suggesting that the vaccine may provide some cross-protection against the disease, particularly in reducing deaths.

WHO’s Technical Advisory Group on Candidate Vaccine Prioritisation made the recommendation at its third meeting on 31 July, after reviewing available evidence on the vaccine’s safety, efficacy, availability and feasibility.

The development comes as the DRC continues to respond to an outbreak of Ebola disease caused by the Bundibugyo virus, which was declared on 15 May 2026.

As of 30 July, WHO had recorded 3,605 confirmed cases and 1,587 deaths from the outbreak in the DRC.

Why Ervebo is being considered

The advisory group’s recommendation is significant because Ervebo was developed specifically against Ebola virus disease caused by the Ebola Zaire virus, rather than the Bundibugyo virus.

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According to WHO, the group initially advised against using Ervebo outside carefully designed research settings because its effectiveness against Bundibugyo virus disease remained uncertain.

However, preliminary animal study data indicate that Ervebo may confer some cross-protection against Bundibugyo virus disease, particularly by reducing mortality.

The latest evidence prompted the advisory group to recommend that Ervebo be prioritised for a randomised clinical trial to determine its effectiveness against the disease.

What is the Bundibugyo virus?

The Bundibugyo virus causes Ebola disease. It is distinct from the Ebola virus that Ervebo was specifically developed to protect against.

The Bundibugyo virus disease outbreak in the DRC is the first of its kind in the country. WHO says there is currently no licensed vaccine or specific treatment for Bundibugyo virus disease.

The disease is a severe infection, and previous Bundibugyo virus disease outbreaks have recorded case fatality rates ranging from 30 to 50 per cent, according to WHO.

Safety concerns

According to WHO, the advisory group found no identified safety concerns with the use of Ervebo among contacts of confirmed cases during a Bundibugyo virus disease outbreak.

READ ALSO: WHO raises alarm as DR Congo’s Ebola outbreak surpasses 3,600 cases

However, the experts stressed that the vaccine’s effectiveness against Bundibugyo virus disease and its ability to prevent transmission have not been established.

They therefore recommended that these questions be evaluated through clinical research.

WHO said a vaccine specifically developed against the Bundibugyo virus would remain the preferred option, although preliminary data on such candidates are currently unavailable.

The advisory group also emphasised the need to facilitate large-scale vaccine production and access if future evidence demonstrates sufficient efficacy to protect affected populations.


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Health

NARD demands prosecution over alleged assault of doctor at Abuja hospital

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The Nigerian Association of Resident Doctors (NARD) has called for the immediate arrest and prosecution of two people allegedly involved in the assault of a medical officer at Gwarinpa General Hospital, Lifecamp, Abuja.

NARD made the demand in a statement issued on Friday, following the alleged assault of a senior medical officer while on call at the hospital’s Accident and Emergency Unit on 31 August.

According to the association, a patient physically attacked the doctor and his companion following a disagreement over his clinical assessment.

The alleged assailants also threatened the doctor and his family, NARD said.

The association described the incident as unacceptable, saying it posed a serious threat to the safety, dignity and welfare of healthcare workers providing essential services to the public.

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48-hour service reduction

NARD said it supports the Association of Resident Doctors, FCT Administration (ARD-FCTA), resolution to embark on a 48-hour step-down of services at Gwarinpa General Hospital.

The action commenced at 8 a.m. on 3 September and is expected to end at 8 a.m. on 5 September.

The association said the action was in line with the North Central Caucus Guidelines for responding to assaults against its members.

NARD commended the leadership and Congress of ARD-FCTA for exercising “patience, restraint, and maturity” by giving relevant authorities a reasonable time to address the matter.

NARD demands action

The doctors’ association called on the Nigeria Police Force and other security agencies to immediately apprehend, investigate, and prosecute the alleged assailants in accordance with the law.

“Any delay in taking decisive action risks creating a dangerous precedent and further exposing healthcare workers to violence,” the association said.

NARD also urged the FCT Hospitals Management Board and other relevant authorities to strengthen security across healthcare facilities, particularly Accident and Emergency Units.

It said improved security was necessary to protect healthcare workers, patients and hospital property.

The association expressed solidarity with the affected doctor and his family, assuring its members that it remained committed to protecting their safety, dignity and welfare.

ALSO READ: Assault on doctor triggers fresh strike at teaching hospital, months after EFCC controversy

“Violence against healthcare workers is unacceptable,” NARD said, stressing that doctors must be allowed to perform their duties in a safe and secure environment.

Recent case

The incident comes amid renewed concerns over violence against healthcare workers and its impact on hospital services.

On Wednesday, resident doctors at the University of Uyo Teaching Hospital (UUTH), Akwa Ibom State, began an indefinite strike following the alleged assault of a house officer by an elderly woman at the hospital.

The Nigerian Medical Association (NMA), Akwa Ibom State branch, gave the hospital management and security agencies 48 hours to identify and prosecute those responsible for the alleged assault.

The Uyo action followed another disruption at the same hospital in May, when doctors embarked on an indefinite strike after an operation by officials of the Economic and Financial Crimes Commission (EFCC) at the facility triggered controversy over alleged assault and the arrest of hospital workers.


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Yobe govt spends N360m annually on free dialysis scheme

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The Yobe State government spends about N360 million annually to provide free dialysis services at the Yobe State University Teaching Hospital (YSUTH), Damaturu, the hospital’s Chief Medical Director, Baba Goni, has said.

Mr Goni said the hospital conducts between 600 and 700 free haemodialysis sessions every month under the programme, which has been running since 2017.

He disclosed this in an interview with the News Agency of Nigeria (NAN) in Damaturu on Thursday.

According to him, the hospital spends N30 million monthly on the programme.

“In dialysis, you don’t count the number of patients because one patient can have two or three sessions in a week,” he said.

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“The cost of dialysis per session in other teaching hospitals is about N50,000, excluding the cost of drugs, laboratory investigation and admission where necessary.”

Mr Goni said the state government had signed a Memorandum of Understanding (MoU) with a reputable company supplying dialysis consumables to ensure that the treatment was sustained.

He said the hospital also performed free fistula surgeries to have “vascular access” to patients with Chronic Kidney Disease.

According to him, vascular surgeons are usually invited to conduct the procedure on patients while the hospital pays for the services and purchases the required consumables.

The CMD said a water treatment plant and five additional dialysis machines were recently procured, bringing the total number of functional dialysis machines at the facility to 11.

Mr Goni said that plans had reached an advanced stage to establish another dialysis centre at the Specialists’ Hospital, Gashua, the epicentre of kidney disease in the state.

He said the proposed dialysis centre in Gashua was captured in the 2026 budget to justify the commitment of the state government to the project aimed at easing the suffering of the people.

“Recently, we travelled to Ghana with the Commissioner for Health, where we negotiated with some partners to bring in these dialysis machines and train our nurses and medical engineers who will maintain them,” he said.

“Very soon, people will start enjoying these services over there, so that they don’t have to bear the inconvenience and transportation cost of coming to Damaturu for the treatment.

“I am using this medium to appeal to our people for their understanding of the complex nature of planning and implementation of government projects, which usually take some time.”

Mr Goni announced that a preliminary report on the 2025 kidney disease research, sponsored by the state and conducted in Gashua, would soon be submitted to Governor Mai Mala Buni for necessary action.

He, however, said the report would be thoroughly scrutinised before causality could be established because drawing conclusions on things that were not clear could have economic consequences.

READ ALSO: Katsina health workers to begin 7-day warning strike 8 Sept

“Sometimes the report may suggest action to be taken against the economic livelihood of the communities. We don’t want to do that if we are not fully convinced because poverty is also a problem.

“Remember, during the COVID-19 pandemic, communities were locked down, and the consequences were worse than COVID because many people could not go out to fend for their families,” he said.

Mr Goni said the state and the Urology and Nephrology Centre, Mansoura in Egypt, had, in 2018, signed a Memorandum of Understanding (MoU) for training doctors and other specialists at the YSUTH on kidney transplant.

He said although, the programme was obstructed by the COVID-19 pandemic, efforts were made to resume its implementation.

(NAN)


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