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WHO recommends clinical trial of Ebola vaccine against Bundibugyo virus

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The World Health Organisation (WHO) has recommended that a vaccine called Ervebo be prioritised for a randomised clinical trial against Bundibugyo virus disease in the Democratic Republic of Congo (DRC).
The recommendation followed preliminary animal study data suggesting that the vaccine may provide some cross-protection against the disease, particularly in reducing deaths.

WHO’s Technical Advisory Group on Candidate Vaccine Prioritisation made the recommendation at its third meeting on 31 July, after reviewing available evidence on the vaccine’s safety, efficacy, availability and feasibility.

The development comes as the DRC continues to respond to an outbreak of Ebola disease caused by the Bundibugyo virus, which was declared on 15 May 2026.

As of 30 July, WHO had recorded 3,605 confirmed cases and 1,587 deaths from the outbreak in the DRC.

Why Ervebo is being considered

The advisory group’s recommendation is significant because Ervebo was developed specifically against Ebola virus disease caused by the Ebola Zaire virus, rather than the Bundibugyo virus.

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According to WHO, the group initially advised against using Ervebo outside carefully designed research settings because its effectiveness against Bundibugyo virus disease remained uncertain.

However, preliminary animal study data indicate that Ervebo may confer some cross-protection against Bundibugyo virus disease, particularly by reducing mortality.

The latest evidence prompted the advisory group to recommend that Ervebo be prioritised for a randomised clinical trial to determine its effectiveness against the disease.

What is the Bundibugyo virus?

The Bundibugyo virus causes Ebola disease. It is distinct from the Ebola virus that Ervebo was specifically developed to protect against.

The Bundibugyo virus disease outbreak in the DRC is the first of its kind in the country. WHO says there is currently no licensed vaccine or specific treatment for Bundibugyo virus disease.

The disease is a severe infection, and previous Bundibugyo virus disease outbreaks have recorded case fatality rates ranging from 30 to 50 per cent, according to WHO.

Safety concerns

According to WHO, the advisory group found no identified safety concerns with the use of Ervebo among contacts of confirmed cases during a Bundibugyo virus disease outbreak.

READ ALSO: WHO raises alarm as DR Congo’s Ebola outbreak surpasses 3,600 cases

However, the experts stressed that the vaccine’s effectiveness against Bundibugyo virus disease and its ability to prevent transmission have not been established.

They therefore recommended that these questions be evaluated through clinical research.

WHO said a vaccine specifically developed against the Bundibugyo virus would remain the preferred option, although preliminary data on such candidates are currently unavailable.

The advisory group also emphasised the need to facilitate large-scale vaccine production and access if future evidence demonstrates sufficient efficacy to protect affected populations.


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Health

British national tests positive for Ebola in DRC

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A British national has tested positive for Ebola in the Democratic Republic of the Congo (DRC), the UK government has confirmed.

According to the BBC, the British man tested positive for the virus while in the DRC. Reuters subsequently reported that he would be medically evacuated to the UK for specialist treatment. However, the exact time of the evacuation was not immediately known.

This marks the first confirmed case of a British national contracting the virus during the ongoing outbreak in the DRC, which has claimed more than 5,000 lives.

Ebola is a viral disease that can cause severe illness and spreads mainly through direct contact with the blood or other bodily fluids of an infected person.

Symptoms include fever, headache, vomiting, muscle pain, weakness, and diarrhoea.

“The UK has well-established procedures for dealing with cases like this, and those processes have been activated,” a UK government spokesperson was quoted as saying.

“Further information will be shared in due course as appropriate. The risk to the UK public from Ebola remains low.”

Ebola outbreak

The current outbreak is caused by the Bundibugyo virus, a species of Ebola virus, and was first declared in DRC in May 2026.

According to the latest figures from the United States Centres for Disease Control and Prevention (CDC), the outbreak had recorded 10,563 confirmed cases and 5,130 deaths across five countries as of 1 November 2026.

The DRC accounts for the majority of the cases, with 10,532 confirmed cases and 5,126 deaths. The outbreak has affected eight provinces in the country.

Kenya has recorded nine confirmed cases and two deaths, while Uganda has recorded 20 confirmed cases and two deaths, alongside one probable case and one probable death.

Nigeria confirmed its first case on 20 October after a traveller with a history of travel to Uganda tested positive for the virus. The patient was subsequently medically evacuated to Switzerland for treatment.

According to the European Centre for Disease Prevention and Control (ECDC), 62 contacts linked to the Nigerian case had been identified and were under follow-up as of 29 October.

Symptoms and transmission

The World Health Organisation (WHO) has explained that Ebola survivors may transmit the virus through sexual intercourse if it persists in their semen after recovery.

However, survivors who have met the criteria for discharge from treatment are not expected to transmit the virus through sweat or saliva, as the virus is cleared from their blood.

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Six climate measures could save 1.6 million lives yearly – WHO

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Six proven climate and health interventions could prevent 1.6 million deaths annually and generate trillions of dollars in economic benefits if implemented globally, the World Health Organisation (WHO) has revealed.

The measures, which include heat-health warning systems, access to safe water and sanitation, cleaner household energy and more efficient fossil fuel pricing policies, could generate $3.9 trillion in annual economic welfare benefits and a further $5.4 trillion in fiscal gains.

The WHO disclosed this in a new report titled ‘Global benefits and costs of prioritised actions on climate change and health’, released ahead of the 31st United Nations Climate Change Conference (COP31), where countries are expected to present their climate commitments.

According to the report, the six interventions could prevent one in every 40 deaths globally, based on modelled projections, while avoiding 16.7 billion tonnes of carbon dioxide emissions annually.

The estimated emissions reduction is equivalent to 31 per cent of global annual greenhouse gas emissions, excluding emissions from land use, land-use change and forestry.

The report, which the WHO described as its first comprehensive assessment of the economic and fiscal returns from scaling up the six recommended interventions, highlights the potential health and financial gains of integrating public health considerations into climate policies.

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It argues that many health consequences of climate change are preventable through existing solutions, but governments must implement them across health and other sectors that determine people’s health.

Six interventions

The report identifies six interventions: heat-health warning systems, climate-resilient drinking-water services, basic sanitation services, hygiene and handwashing facilities, cleaner household fuels and technologies for cooking and heating, and efficient fossil fuel pricing policies.

The WHO estimates that five of the interventions could generate $24 in benefits for every $1 invested, with returns expected to be greater in low- and middle-income countries.

Heat-health warning systems are projected to deliver particularly high returns, generating an estimated $835 in benefits for every $1 invested.

The report attributes the high returns to the relatively low cost of expanding existing warning systems and their potential to prevent heat-related illnesses.

Efficient fossil fuel pricing policies, however, are projected to deliver the largest overall gains.

Such policies, including removing inefficient fossil fuel subsidies and appropriately taxing fossil fuels, could prevent 1.2 million deaths annually while generating $3 trillion in economic welfare benefits and $5.4 trillion in fiscal gains.

Health at the centre of climate action

Commenting on the findings, WHO Director-General Tedros Ghebreyesus said the climate crisis was also a health crisis, but many of its consequences could be prevented using existing interventions.

READ ALSO: WHO raises alarm as 75% of diabetes cases in Africa remain undiagnosed

He said expanding proven and affordable interventions could save millions of lives, particularly in countries with the greatest need.

“The climate crisis is a health crisis, but much of the harm it causes can be prevented with tools we already have,” he said.

Mr Ghebreyesus urged governments to place health considerations at the centre of climate action as they prepare for the next round of international climate negotiations.

The WHO said countries were already experiencing record-breaking climate shocks in 2026, investing in measures that protect human health and the environment increasingly urgent.

The health body called on governments, development partners and financing institutions to use the economic evidence to scale up the interventions, noting that they could deliver simultaneous benefits for public health, climate mitigation and national economies.


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