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CEPI invests $1.9m to accelerate Ebola Vaccine development

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The Coalition for Epidemic Preparedness Innovations (CEPI) has awarded $1.9 million to accelerate the development of a vaccine candidate against the Bundibugyo ebolavirus, as global health partners intensify efforts to respond to ongoing outbreaks in parts of Africa.

The funding was announced in a statement published on CEPI’s website on Monday and awarded to Public Health Vaccines, LLC (PHV), a long-standing partner of the coalition.

According to CEPI, the investment will support the rapid production of Master Viral Seed stock required to advance the investigational vaccine into clinical testing.

It noted that the Bundibugyo outbreak had resulted in more than 560 confirmed infections and over 100 confirmed deaths.

The statement added that no licensed vaccine currently exists against the Bundibugyo virus and none is in clinical development.

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It also said CEPI could support future clinical trials if development milestones are achieved, paving the way for emergency use authorisation or eventual licensure.

It added that PHV had committed to ensuring rapid and affordable access to any successful vaccine for affected countries and vulnerable populations.

The coalition said the investment represented its fourth commitment to investigational Bundibugyo vaccine candidates, reflecting efforts to diversify research approaches.

According to CEPI, parallel investments across several vaccine platforms improve the likelihood of delivering safe and effective vaccines within shorter timelines.

The organisation said it had also mobilised laboratory networks, clinical trial partners, manufacturers and regulators to strengthen outbreak response and vaccine development activities.

It added that collaboration was ongoing with Gavi, the World Bank and other development finance institutions to explore financing options for manufacturing and procurement.

The organisation said the Bundibugyo outbreak, alongside a recent hantavirus outbreak, highlighted the importance of sustained investment in epidemic preparedness and scientific innovation.

In the statement, CEPI Chief Executive Officer, Richard Hatchett, described the epidemic as a reminder of how rapidly dangerous viruses could spread in vulnerable communities.

“This epidemic is a stark reminder of how quickly deadly viruses can spread, especially in communities already under immense strain.

“Vaccines could play an important role in bringing the outbreak under control,” Mr Hatchett said.

He said the vaccine candidate used the recombinant vesicular stomatitis virus platform, the same technology employed in a licensed vaccine against Zaire ebolavirus.

“The rVSV platform has demonstrated its value when responding to previous Zaire ebolavirus outbreaks.

“This same technology could now be vital in saving lives against Bundibugyo,” he said.

Mr Hatchett stressed that specialised processes and critical research materials required for vaccine development take time to establish, making early investment essential.

READ ALSO: Tinubu establishes Ebola task force, approves ₦10bn for preparedness

Also speaking, PHV Chief Business Officer, Michael McGinnis, welcomed the expanded partnership and expressed confidence in the vaccine candidate’s potential contribution to outbreak control efforts.

“We are grateful for the opportunity to expand our existing partnership with CEPI to now include our Bundibugyo ebolavirus vaccine candidate.

“We look forward to making a meaningful contribution to this and future outbreaks,” Mr McGinnis said.

The News Agency of Nigeria (NAN) reports that Bundibugyo Ebola virus is one of the forms of Ebola virus that causes severe haemorrhagic fever in humans.

It was first identified in Uganda in 2007 and can spread through direct contact with infected bodily fluids.

(NAN)


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Cholera Outbreak: 74 dead, over 7,800 cases strain Borno facilities

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A cholera outbreak has infected thousands of people and placed growing pressure on health facilities in Borno State, with 74 deaths and 7,850 suspected cases recorded in the state since early May.

In a statement issued on 9 June, the international medical humanitarian organisation Médecins Sans Frontières (MSF), also known as Doctors Without Borders, said the outbreak had spread across 14 local government areas and 50 wards, citing figures from the Borno State Ministry of Health.

According to the organisation, the number of patients requiring urgent treatment has been rising since the first suspected case was reported on 1 May.

Health facilities stretched by rising admissions

MSF said it partnered with the Borno State Ministry of Health to establish a Cholera Treatment Centre (CTC) in the Ngarannam area of Maiduguri on 7 May to support the response.

Patients with suspected cholera receiving initial sstabilisationin the triage of the cholera treatment centre run by MSF in collaboration with the State Ministry of Health in Ngarannam, in Maiduguri, Borno state (CREDIT: Merel van de Geyn/MSF)
Patients with suspected cholera receiving initial sstabilisationin the triage of the cholera treatment centre run by MSF in collaboration with the State Ministry of Health in Ngarannam, in Maiduguri, Borno state (CREDIT: Merel van de Geyn/MSF)

The organisation said admissions increased rapidly in the weeks that followed, forcing an expansion of the facility’s bed capacity from 121 to 271.

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It added that a separate 20-bed Cholera Treatment Unit (CTU) had been opened in the Dalaram area of the state capital to accommodate the growing number of patients.

As of 7 June, MSF said it had treated 7,439 patients at the two facilities, averaging about 230 admissions per day.

A wide shot of patients with suspected cholera receiving treatment at the cholera treatment unit run by MSF in collaboration with the State Ministry of Health in Dalaram, in Maiduguri, Borno state (CREDIT: Merel van de Geyn/MSF
A wide shot of patients with suspected cholera receiving treatment at the cholera treatment unit run by MSF in collaboration with the State Ministry of Health in Dalaram, in Maiduguri, Borno state (CREDIT: Merel van de Geyn/MSF

The organisation added that more than 500 patients suffering from acute watery diarrhoea were admitted on 5 June alone, the highest single-day admission figure recorded since the response began.

“Every day, we see more people arriving with severe watery diarrhoea and dehydration, many of whom have travelled long distances to reach care,” said Bienfait Tombola, MSF’s project medical coordinator for the emergency response in Maiduguri.

“The collaboration between the Ministry of Health, MSF and other partners has enabled a rapid scale-up of several aspects of the response, but the continued increase in cases shows that more needs to be done to prevent transmission and ensure people can access care as early as possible,” he said.

Vaccination, water access key to containment

Beyond treating patients, MSF said it is supporting healthcare worker training, establishing oral rehydration points in affected communities, conducting health promotion activities, strengthening disease surveillance and referral systems, and supporting water chlorination and sanitation interventions.

MSF infection prevention and control manager James Moriea standing at the entrance of the wards of the cholera treatment centre run by MSF in collaboration with the State Ministry of Health in Ngarannam, in Maiduguri, Borno state. ©Merel van de Geyn/MSF
MSF infection prevention and control manager James Moriea standing at the entrance of the wards of the cholera treatment centre run by MSF in collaboration with the State Ministry of Health in Ngarannam, in Maiduguri, Borno state (CREDIT: Merel van de Geyn/MSF

However, the organisation warned that the scale and speed of the outbreak continue to exceed current response capacity.

MSF noted that cholera and other water-borne diseases thrive in communities with inadequate access to clean water, sanitation facilities, hygiene infrastructure and healthcare services, particularly in informal settlements.

READ ALSO: Cholera kills 37 in Borno, endangers 3,000 lives

Mr Tombola said a cholera vaccination campaign planned by the Ministry of Health could help reduce transmission. Still, it stressed that long-term investments in water, sanitation and hygiene infrastructure remain critical.

“While treatment is essential to save lives, a cholera vaccination is foreseen to be conducted by the Ministry of Health, and this would help cut the chains of transmission,” he said.

“Sustainable improvements in access to clean water, sanitation and hygiene are equally critical to reducing transmission and preventing risks of a continued surge in cases of waterborne diseases.”

MSF said it would continue supporting the Borno State Ministry of Health and other partners in efforts to contain the outbreak and provide lifesaving care to affected communities.


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Lagos issues hotels, clubs, establishments preventive hygiene guidelines against Ebola outbreak

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The Lagos State Safety Commission has directed hotels, nightclubs, event centres, lounges, restaurants and other hospitality businesses across the state to strengthen hygiene and safety measures following the Ebola outbreak reported in parts of Central and East Africa.

The commission, however, stressed that there is currently no confirmed case of Ebola in Lagos or anywhere in Nigeria, noting that the advisory is a precautionary measure aimed at protecting residents and visitors.

The directive comes amid intensified biosecurity screening by the federal government at the Murtala Muhammed International Airport as authorities seek to prevent the importation of the virus.

The latest advisory also follows recent efforts by Lagos health authorities to assess the state’s preparedness for any potential outbreak.

Officials have inspected screening and emergency response facilities at the Murtala Muhammed International Airport, Ikeja, Lagos, saying the exercise was aimed at strengthening surveillance and ensuring rapid response capacity while maintaining that Nigeria has not recorded any Ebola case.

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In a statement on Tuesday, the Director-General of the Lagos State Safety Commission, Lanre Mojola, said the state’s position as Nigeria’s commercial hub and a major international gateway makes it necessary to adopt proactive measures against potential public health threats.

“The Commission strongly emphasises that there is currently no confirmed case of Ebola within Lagos State or Nigeria; however, the city’s status as a major international travel hub and commercial epicentre necessitates immediate, proactive measures to safeguard residents and visitors alike,” the statement stated.

According to the commission, operators of high-density public venues, including hotels, nightclubs, event centres, lounges and restaurants, should lead efforts to prevent possible transmission because of the close-contact nature of their operations.

To that end, it enjoined all establishments to significantly increase the frequency of cleaning and disinfection routines, utilising hospital-grade disinfectants on all high-touch surfaces such as countertops, door handles, handrails, menus, and payment terminals.

It also urged management teams to properly train front-of-house, housekeeping, and security personnel to recognise early symptoms of illness, implement daily health checks for staff, and enforce a strict stay-at-home policy for any employee exhibiting signs of fever.

The advisory also requires hospitality establishments to designate temporary, well-ventilated isolation areas where patrons or staff who suddenly become seriously ill can be kept safely while awaiting medical evacuation.

In addition, venue operators were advised to manage crowd sizes to prevent excessive overcrowding and ensure adequate ventilation in enclosed spaces.

Mr Mojola called on operators to remain calm, vigilant and fully cooperative, adding that safety inspectors would intensify routine compliance and support visits across the state.

He also directed that any suspected medical emergency involving severe fever or illness should be immediately isolated and reported through the Lagos State health emergency hotlines: 08023169485, 08033565529 or 07000SAFETY.

The advisory follows growing concern over the Ebola outbreak in parts of Central and East Africa. According to an NBC report, more than 40 people have died in the Democratic Republic of the Congo and Uganda, where health authorities and international aid agencies are working to contain the spread of the disease.

The World Health Organisation has described the current Bundibugyo strain of the virus as “a severe and often fatal form” of Ebola.

The WHO and the Africa Centres for Disease Control and Prevention reported 43 confirmed deaths across the two countries as of 30 May, comprising 42 in the Democratic Republic of the Congo and one in Uganda. The agencies also said 349 suspected deaths had been recorded.

READ ALSO: WHO raises Ebola risk level as DRC outbreak worsens, reports new hantavirus cases

According to the WHO, Ebola is believed to originate from fruit bats and can spread to humans through contact with bodily fluids or secretions from infected wildlife.

Nigeria’s response is informed by its successful containment of the 2014 Ebola outbreak, which began after an infected traveller arrived in Lagos and was halted through aggressive surveillance, contact tracing and public health interventions.

Health authorities say the experience strengthened the country’s disease surveillance and emergency response systems, which are now being deployed as a precaution against the latest regional outbreak.

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