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CEPI invests $1.9m to accelerate Ebola Vaccine development

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The Coalition for Epidemic Preparedness Innovations (CEPI) has awarded $1.9 million to accelerate the development of a vaccine candidate against the Bundibugyo ebolavirus, as global health partners intensify efforts to respond to ongoing outbreaks in parts of Africa.

The funding was announced in a statement published on CEPI’s website on Monday and awarded to Public Health Vaccines, LLC (PHV), a long-standing partner of the coalition.

According to CEPI, the investment will support the rapid production of Master Viral Seed stock required to advance the investigational vaccine into clinical testing.

It noted that the Bundibugyo outbreak had resulted in more than 560 confirmed infections and over 100 confirmed deaths.

The statement added that no licensed vaccine currently exists against the Bundibugyo virus and none is in clinical development.

It also said CEPI could support future clinical trials if development milestones are achieved, paving the way for emergency use authorisation or eventual licensure.

It added that PHV had committed to ensuring rapid and affordable access to any successful vaccine for affected countries and vulnerable populations.

The coalition said the investment represented its fourth commitment to investigational Bundibugyo vaccine candidates, reflecting efforts to diversify research approaches.

According to CEPI, parallel investments across several vaccine platforms improve the likelihood of delivering safe and effective vaccines within shorter timelines.

The organisation said it had also mobilised laboratory networks, clinical trial partners, manufacturers and regulators to strengthen outbreak response and vaccine development activities.

It added that collaboration was ongoing with Gavi, the World Bank and other development finance institutions to explore financing options for manufacturing and procurement.

The organisation said the Bundibugyo outbreak, alongside a recent hantavirus outbreak, highlighted the importance of sustained investment in epidemic preparedness and scientific innovation.

In the statement, CEPI Chief Executive Officer, Richard Hatchett, described the epidemic as a reminder of how rapidly dangerous viruses could spread in vulnerable communities.

“This epidemic is a stark reminder of how quickly deadly viruses can spread, especially in communities already under immense strain.

“Vaccines could play an important role in bringing the outbreak under control,” Mr Hatchett said.

He said the vaccine candidate used the recombinant vesicular stomatitis virus platform, the same technology employed in a licensed vaccine against Zaire ebolavirus.

“The rVSV platform has demonstrated its value when responding to previous Zaire ebolavirus outbreaks.

“This same technology could now be vital in saving lives against Bundibugyo,” he said.

Mr Hatchett stressed that specialised processes and critical research materials required for vaccine development take time to establish, making early investment essential.

Also speaking, PHV Chief Business Officer, Michael McGinnis, welcomed the expanded partnership and expressed confidence in the vaccine candidate’s potential contribution to outbreak control efforts.

“We are grateful for the opportunity to expand our existing partnership with CEPI to now include our Bundibugyo ebolavirus vaccine candidate.

“We look forward to making a meaningful contribution to this and future outbreaks,” Mr McGinnis said.

The News Agency of Nigeria (NAN) reports that Bundibugyo Ebola virus is one of the forms of Ebola virus that causes severe haemorrhagic fever in humans.

It was first identified in Uganda in 2007 and can spread through direct contact with infected bodily fluids.

(NAN)

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Nigeria launches first mental health policy tracker to monitor implementation of reforms

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Nigeria has launched its first public-facing Mental Health Policy Commitment Tracker, a digital platform designed to independently monitor implementation of the country’s mental health laws and policies amid concerns over slow progress in carrying out key reforms.

Developed by advocacy organisation Nigerian Mental Health (NMH), the tracker was officially launched virtually on Monday after an initial public unveiling in May.

NMH announced the launch in a statement sent to PREMIUM TIMES.

According to the organisation, the platform enables policymakers, researchers, civil society organisations and members of the public to monitor progress on commitments under the National Mental Health Act and related policies, including mental health financing, workforce development, treatment access and state-level reforms.

Why the tracker matters

Late President Muhammadu Buhari signed the National Mental Health Bill into law in January 2023 after two failed legislative attempts dating back to 2003. 

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The legislation replaced the outdated Lunacy Act and marked a major shift in Nigeria’s approach to mental healthcare by strengthening the rights of people living with mental health conditions and providing for institutions such as a Department of Mental Health Services and a Mental Health Fund.

However, more than three years later, implementation of several provisions of the law has remained slow.

According to NMH, key institutional structures required under the Act, including the Department of Mental Health, have yet to be fully established. 

The organisation also said the federal government missed its December 2025 target to fully decriminalise attempted suicide, while implementation of the 2023 National Mental Health Policy and the country’s first Suicide Prevention Policy Framework has been limited.

It said these implementation gaps informed the development of the tracker, which is intended to independently verify whether mental health commitments are being translated into concrete action.

Speaking at the launch, NMH founder Chime Asonye said policy commitments should be accompanied by measurable implementation.

“Visibility must be matched by measurable execution,” he said, adding that the platform is designed to ensure commitments lead to tangible legal, institutional and service delivery outcomes.

According to NMH, the tracker serves as a public dashboard that aggregates government data, legislative updates, budget documents, verified stakeholder submissions and community-reported evidence.

Each policy commitment is assigned an implementation status, such as “Not Started, In Progress, Delayed or Completed”, allowing users to monitor progress across the federal and state levels.

The platform tracks regulatory milestones under the National Mental Health Act, as well as governance structures, budget allocations, workforce capacity, access to treatment, affordability and broader rights-based reforms.

Stakeholders back initiative

The launch brought together government officials, policymakers, researchers, civil society organisations, development partners, media practitioners and representatives of the creative industry.

Among the organisations supporting the initiative are Lagos Mind, Mind Over Matters NG, Stilt NG, Our Beta Life, the Mental Health Transformation Organisation (MHT) and Hevolve Foundation.

Mental health advocate and musician Hadiza Blell-Olo, popularly known as Di’ja, urged public figures to move beyond raising awareness by supporting partnerships that strengthen mental health reforms, noting that the tracker provides a framework for improving policy accountability.

Also speaking, the National Mental Health Coordinator at the Federal Ministry of Health and Social Welfare, Tunde Ojo, said independent accountability mechanisms can help strengthen implementation and improve service delivery.

NMH said the platform is open to policymakers, practitioners, researchers and members of the public, who can submit verified implementation updates and feedback to improve transparency and support mental health reforms across the country.


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DRC Ebola cases rise to 1,274, 96 health workers infected

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The Africa Centres for Disease Control and Prevention (Africa CDC) says the worsening Ebola outbreak in the Democratic Republic of the Congo (DRC) has reached 1,274 confirmed cases.

The agency also said infections among healthcare workers have risen to 96.

Wazih Cho, Data Analyst and Epidemic Intelligence Officer at Africa CDC, disclosed this on Monday during a webinar on the Ebola outbreak.

“In the past 24 hours, 47 new confirmed Ebola cases and 12 deaths were reported in the DRC, 96 per cent of which originated in Équateur Province,” he said.

“Cumulative figures now stand at 1,274 confirmed cases with 360 deaths, indicating sustained transmission at the provincial level.”

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He said Équateur Province accounted for 45 of the 47 new cases reported, making it the leading hotspot of transmission on the continent.

Mr Cho attributed the spread partly to exposure in health facilities, noting that 92 healthcare workers had been infected in the DRC and four in Uganda, bringing the total to 96.

According to him, confirmed cases have now been reported in 35 health zones across the DRC, indicating widespread transmission beyond the initial epicentre.

“For Uganda, cumulatively we have 20 confirmed cases, mostly spillover from DRC. That includes 15 imported cases, four healthcare worker infections, and two fatalities.

“All Uganda cases are classified under Kampala. Contact follow-up in Uganda stands at 100 per cent, with only nine contacts still under active monitoring. Case fatality in Uganda as of day 27 is 10 per cent,” he said.

Mr Cho said Uganda had recorded no new Ebola case since 21 June, although active surveillance remained in place.

More cases

He added that 23 of the 36 health areas in Équateur Province had confirmed cases, confirming sustained community transmission within the province.

According to him, North Kivu, which borders Équateur and Uganda, is also reporting cases, while South Kivu has recorded no new infections for at least 30 days after reporting three cases.

Mr Cho added that Africa CDC also received alerts on 28 June from Tshopo Province, which borders Ituri Province and South Sudan.

He said two confirmed male cases recorded between 9 June and 23 June suggested the outbreak had spread into a previously unaffected province.

According to Cho, the epidemic curve indicates that the first positive case was detected late, after community transmission had already begun.

He said seven-day and three-day moving averages showed the outbreak remained at or near peak transmission, with modelling projecting additional case increases over the next three weeks.

Mr Cho added that a small number of health zones accounted for about 80 per cent of confirmed cases, while several treatment centres were operating above capacity.

He said more than 20,000 community health workers had been mobilised to strengthen case detection, contact tracing and community sensitisation efforts.

In his remark, Oyewale Tomori, former President of the Nigeria Academy of Science, commended Africa CDC and the World Health Organisation (WHO) for working collaboratively in responding to the outbreak.

Mr Tomori described the One Health approach as an integrated strategy recognising the close links between human, animal and environmental health.

He said that about 70 per cent of emerging infectious diseases were zoonotic, spreading from animals to humans.

READ ALSO: Nigeria responds with emergency funds as Ebola death toll rises in DRC

“Ebola, SARS, and other viruses reflect this animal-human interface, with diverse modes of transmission and host species,” he said.

Mr Tomori identified deforestation, urban expansion, mining, conflict-driven migration, bushmeat trade, climate change and weak public health systems as major drivers of emerging infectious diseases.

He emphasised that stronger surveillance, early detection and coordinated response systems were essential to preventing and containing outbreaks before they escalated.

Mr Tomori said One Health required veterinarians, physicians, social scientists, engineers and economists to work together to achieve effective outbreak prevention and response.

(NAN)


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