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WHO prioritises clinical trials for Bundibugyo Ebola treatments, vaccines

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Health experts have advised that all candidate treatments and vaccines for Ebola disease caused by the Bundibugyo virus should be used exclusively within clinical trials to ensure safe, ethical, and effective research.

A statement made available on Thursday said that the experts were convened by the World Health Organisation (WHO).

According to it, the recommendation comes in response to the current outbreak in the Democratic Republic of the Congo, with additional cases reported in Uganda, and follows assessments by multiple WHO experts and advisory groups.

“WHO convened meetings with its Research and Development (R&D) Blueprint technical advisory groups on candidate vaccines and therapeutics for Bundibugyo Virus Disease (BVD) to evaluate options for both prevention and treatment.

“In parallel, the Strategic Advisory Group of Experts on Immunisation and its Ebola vaccine working group reviewed the potential role of licensed Ebola vaccines during BVD outbreaks,” it said.

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The statement said that there are currently no licensed therapeutics or vaccines specifically approved for the prevention and treatment of BVD, though several candidate products were identified as promising enough to prioritise for clinical trial evaluation.

It noted that for treatment of confirmed BVD cases, independent experts recommended prioritising three candidates: the monoclonal antibodies MBP134 and Maftivimab®, and the antiviral remdesivir.

“Combination therapy using a monoclonal antibody and remdesivir was also recommended for evaluation in research settings.

“For prevention, the oral antiviral obeldesivir was identified as a priority candidate for post-exposure prophylaxis among contacts of confirmed and probable cases,” it said.

According to it, experts noted that post-exposure prophylaxis with obeldesivir depends on effective contact tracing, which remains operationally challenging in some affected areas of the DRC.

It said the most promising vaccine candidate is the single-dose rVSV Bundibugyo vaccine being developed by the International AIDS Vaccine Initiative, though it is expected to require 7–9 months before it is ready for clinical trial assessment.

It said that another candidate, ChAdOx1 Bundibugyo from Oxford University and the Serum Institute of India, could potentially be available within two to three months for efficacy testing, pending additional animal data.

“Experts suggested a single-dose approach for contacts of cases, while a two-dose strategy might be considered for high-risk but unexposed populations such as health-care workers and frontline responders.

READ ALSO: Ebola: WHO says conflict, mistrust hindering response as suspected cases top 900 in DRC

“The groups also reviewed Ervebo, the only licensed Ebola vaccine, which is approved for outbreaks caused by the most common Ebola virus in Africa but is not licensed for BVD and lacks conclusive evidence of cross-protection,” it said.

The statement said that the WHO recommended that Ervebo should not be used outside carefully designed research settings to allow its performance against BVD to be properly assessed.

“WHO, the governments of the DRC and Uganda, Africa CDC, ANRS Emerging Infectious Diseases, and other partners are now working to develop protocols for clinical field trials.

“While continuing to rely on established Ebola response measures like surveillance, contact tracing, isolation, testing, community engagement, and safe burials to stop transmission,” it said. (NAN)


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World Breastfeeding Week: FG urges stronger support for breastfeeding

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The Federal Ministry of Health and Social Welfare has called on Nigerians to strengthen support for breastfeeding by creating enabling environments for mothers at home, in communities, healthcare facilities and workplaces.

The ministry made the call in a statement issued on Tuesday in Abuja by its Assistant Director of Information and Public Relations, Ado Bako, ahead of the 2026 World Breastfeeding Week.

The global event, observed annually from 1 to 7 August, will be commemorated this year under the theme, “Breastfeeding for a Sustainable Start in Life: Strengthen What Works.”

Mr Bako said the theme highlights the need to build on proven strategies that have improved breastfeeding practices while advancing better nutrition, food security and poverty reduction.

He described breastfeeding as the foundation of lifelong health, noting that it provides optimal nutrition for infants, strengthens immunity and supports healthy brain development.

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“Breastfeeding supports healthy brain development, improves child survival and contributes significantly to human capital development and national productivity,” he said.

Mr Bako added that promoting and protecting breastfeeding also reduced healthcare costs, while advancing food security and social equity.

The ministry emphasises that every mother deserves the support needed to breastfeed successfully.

“Families, healthcare providers, employers, communities and policymakers all have critical roles in ensuring that breastfeeding mothers receive adequate care, encouragement and workplace support,” he said.

Mr Bako reiterated the ministry’s recommendations on optimal infant feeding practices, including early initiation of breastfeeding within one hour of birth and exclusive breastfeeding for the first six months of life.

He also emphasised the introduction of appropriate complementary foods from six months, while continuing breastfeeding up to two years old or beyond.

He noted that breastmilk remained the ideal food for infants because it was safe, readily available, affordable and hygienic, while providing the first line of protection against many common childhood illnesses.

READ ALSO: UNICEF advocates exclusive breastfeeding to protect children against diphtheria

According to him, increased breastfeeding also helps families avoid the high financial burden associated with infant formula and preventable diseases.

Mr Bako said activities lined up for the 2026 World Breastfeeding Week would be held nationwide and include a national commemoration on 3 August.

Other activities, he said, include a media conference by the Coordinating Minister of Health and Social Welfare, community outreach programmes among others.

He called on Nigerians to support mothers in breastfeeding according to national recommendations.

“Collective action to protect, promote and support breastfeeding is an investment in healthier children, stronger families and a more prosperous Nigeria,” Mr Bako said. (NAN)


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WHO urges Africa to expand access to hepatitis care

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The World Health Organisation (WHO) has urged African governments to strengthen national hepatitis programmes and expand access to vaccination, testing, and treatment, warning that millions of people across the continent continue to miss out on life-saving services despite the availability of effective interventions.

In a statement issued ahead of World Hepatitis Day, the WHO Regional Director for Africa, Mohamed Janabi, said viral hepatitis remains a major public health challenge across the region, even though new hepatitis B infections declined by 25 per cent between 2015 and 2024.

Mr Janabi noted that while effective vaccines, diagnostics, and treatments are available, many people are still diagnosed too late or cannot access care, leading to preventable deaths.

“No one should die from a disease that can be prevented, diagnosed and, in many cases, treated,” he said.

He called on governments, development partners, health workers, and communities to remove barriers preventing people from accessing hepatitis services.

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“Eliminating viral hepatitis is within our reach, but only if proven interventions are available to everyone who needs them,” he said.

Bringing services closer to communities

Mr Janabi said the region already has the tools needed to eliminate viral hepatitis as a public health threat.

According to him, the hepatitis B vaccine, introduced in the early 1990s, provides up to 95 per cent protection against infection, while reliable diagnostic tools enable early detection. He added that hepatitis C can be cured, and lifelong treatment for hepatitis B can prevent complications such as liver cirrhosis and liver cancer.

He stressed that integrating hepatitis prevention, testing, and treatment into primary healthcare would make services more accessible and affordable, while also reducing pressure on health systems.

Mr Janabi said the challenge is no longer scientific but one of political commitment, financing, and equitable access.

He noted that countries in the WHO African Region have recorded progress by expanding the universal hepatitis B birth dose vaccine, advancing the elimination of mother-to-child transmission of HIV, syphilis, and hepatitis B, and pioneering hepatitis C elimination pathways.

However, he said these gains must be sustained and expanded across all 47 WHO African member states.

Late diagnosis

Mr Janabi warned that many people living with viral hepatitis remain unaware of their infection until serious liver damage has occurred.

He attributed the problem to inadequate access to testing and treatment, particularly in underserved communities, as well as stigma and limited public awareness.

To close these gaps, Mr Janabi urged countries to integrate hepatitis services into routine healthcare throughout a person’s life while investing in research and innovation to improve access to new diagnostic tools and treatments, including for hepatitis B and hepatitis D co-infection.

He also called on development partners to sustain technical and financial support to help countries achieve the global target of eliminating viral hepatitis as a public health threat by 2030.

World Hepatitis Day

Observed annually on 28 July, World Hepatitis Day raises awareness about viral hepatitis and promotes actions to prevent, diagnose, and treat the disease.

This year’s theme, “Hepatitis: Let’s break it down,” calls for breaking down financial, social, and systemic barriers that prevent people from accessing hepatitis services and accelerating progress towards eliminating the disease.

According to the WHO, viral hepatitis causes inflammation of the liver and can lead to severe complications, including liver cirrhosis, liver failure, and liver cancer if left untreated.

Nigeria’s burden

According to the WHO, Nigeria remains one of the countries most affected by viral hepatitis globally. The organisation estimates that more than 20 million Nigerians are living with hepatitis B, hepatitis C or both, yet over 80 per cent do not know their status. Data from the 2018 Nigeria HIV/AIDS Indicator and Impact Survey (NAIIS) also showed a hepatitis B prevalence of 8.1 per cent and a hepatitis C prevalence of 1.1 per cent among adults aged 15 to 64 years.

The burden extends beyond Nigeria. WHO estimates that more than 90 million people across the African Region are living with viral hepatitis, accounting for about 26 per cent of the global burden. Despite ongoing efforts to strengthen hepatitis control programmes, PREMIUM TIMES has previously reported persistent challenges, including low testing rates, limited access to treatment, and gaps in the uptake of the hepatitis B birth dose vaccine, leaving many infections undetected until serious liver complications develop.

Against the backdrop of the region’s high hepatitis burden, Mr Janabi reaffirmed WHO’s commitment to supporting African countries in strengthening health systems and expanding equitable access to hepatitis services.

“Together, we can prevent new infections, save lives and ensure that viral hepatitis is no longer a barrier to healthier lives for the people of Africa,” he said.


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