The Coalition for Epidemic Preparedness Innovations(CEPI) has announced the start of the world’s first human clinical trial of a vaccine developed specifically against the Bundibugyo strain of the Ebola virus, with the first volunteer vaccinated at the University of Oxford.
The announcement was contained in a statement made available to the News Agency of Nigeria (NAN) on Friday by CEPI’s Senior Communications and Advocacy Manager, Jodie Rogers.
The Phase I clinical trial, known as BD-Ebov, will evaluate the safety of the experimental vaccine and its ability to stimulate immune responses in healthy adult volunteers.
The vaccine candidate, ChAdOx1 BDBV, was developed by scientists at the University of Oxford’s Oxford Vaccine Group and the Pandemic Sciences Institute using the same adenoviral vector technology employed in the Oxford/AstraZeneca COVID-19 vaccine.
According to the statement, the milestone comes only weeks after the launch of the BD-Ebov study and marks the first time the ChAdOx1 BDBV vaccine has been administered to humans.
It said the vaccine development programme had progressed rapidly through collaboration among the University of Oxford, its Clinical BioManufacturing Facility, the Serum Institute of India (SII) and CEPI.
The statement added that SII manufactured the vaccine candidate in record time and has stockpiled approximately 620,000 doses, while providing 4,000 investigational doses for the ongoing clinical trial.
CEPI said the trial forms part of an $8.6 million programme supporting the University of Oxford and SII to accelerate the development of a vaccine against the Bundibugyo strain.
Ebola outbreak
NAN reports that the trial comes as the Democratic Republic of the Congo (DRC) battles a severe outbreak of Bundibugyo Ebola Virus Disease, with more than 2,500 confirmed cases and over 1,000 deaths recorded.
Unlike the Zaire strain of Ebola, for which licensed vaccines are available, there is currently no approved vaccine specifically targeting the Bundibugyo strain.
David Pulido-Gomez, Global Chemistry, Manufacturing and Controls Lead at the Pandemic Sciences Institute, said the vaccine candidate moved from concept to clinical evaluation within just eight weeks.
“Reaching this milestone in such a short timeframe reflects an extraordinary collaborative effort,” he said.
“Working alongside colleagues at the Clinical BioManufacturing Facility and the Serum Institute of India, we have taken this vaccine candidate from concept to clinic in just eight weeks.”
The Lead Study Doctor, Peter Skydmore, described the vaccination of the first participant as a significant milestone.
Mr Skydmore said while these are very early days, they represent an important first step in evaluating this vaccine in humans.
“Over the coming months, we will continue vaccinating and monitoring participants while assessing the vaccine’s safety and immune responses,” he said.
Chief Investigator, Katrina Pollock, said the commencement of the trial marked another important phase in the multinational effort to develop a vaccine against the Bundibugyo ebolavirus.
Ms Pollock commended the commitment of research partners and volunteers, saying their participation was critical to responding to the ongoing outbreak.
Commenting on the development, CEPI Chief Executive Officer, Richard Hatchett, said the worsening outbreak in the DRC underscored the urgency of developing a vaccine against the Bundibugyo strain.
“With Bundibugyo cases increasing at a concerning rate in the DRC, this epidemic shows no signs of stopping,” he said.
“The need for a vaccine against this specific Ebolavirus becomes more urgent every day.”
Also speaking, Chief Executive Officer of SII, Adar Poonawalla, said the rapid manufacture of the vaccine candidate demonstrated how scientific innovation and scalable production could accelerate responses to emerging infectious diseases.
He reaffirmed the institute’s commitment to supporting equitable access to vaccines for populations most at risk.
According to the statement, recruitment and vaccination of additional volunteers will continue over the coming weeks, while preparations are underway, subject to regulatory approval, for further clinical studies in Uganda.
It added that if the Phase I trial demonstrates favourable safety and immune responses, CEPI, the University of Oxford and SII will advance to larger late-stage studies to support emergency use authorisation or full regulatory approval.
The partners also pledged to ensure the rapid, affordable and equitable supply of the vaccine to affected countries once it is successfully developed.
About the vaccine
NAN reports that ChAdOx1 BDBV is an experimental vaccine developed specifically to protect against the Bundibugyo strain, one of the species that causes Ebola Virus Disease.
The vaccine uses the ChAdOx1 platform, a harmless chimpanzee adenovirus vector engineered to carry genetic material from the Bundibugyo ebolavirus.
The technology trains the body’s immune system to recognise and fight the virus without causing Ebola infection.
The same ChAdOx1 platform was used to develop the Oxford/AstraZeneca COVID-19 vaccine, which was deployed globally during the COVID-19 pandemic.
Researchers say the existing platform enabled the rapid development of the Bundibugyo vaccine candidate. (NAN)
The Jos North Local Government has intensified disease surveillance and community sensitisation as health authorities work to contain a diphtheria outbreak in Plateau State.
The council’s chairman, John Christopher, on Saturday handed over motorcycles to the local government’s health directorate to strengthen field surveillance, contact tracing and community outreach across the area.
The development is expected to enable health workers to reach communities more quickly, conduct follow-up visits, collect samples and identify suspected cases, particularly in areas that are difficult to access.
The intervention comes amid reported diphtheria cases in the area, where 117 suspected cases and 15 deaths had been recorded as of 1 September, according to health authorities.
Plateau State has also reported suspected cases in Jos South, Bassa and Wase local government areas.
The state government has ordered the temporary closure of public and private primary and secondary schools from Monday as part of measures to contain the spread of the disease.
In Jos North, the council has been working with the state Ministry of Health to strengthen surveillance, case management and community mobilisation.
Mr Christopher said the additional logistics were necessary to ensure that health workers could respond promptly to suspected cases.
“For us, the health and safety of our people remain a priority. Diphtheria spreads fast, and we cannot afford delays,” he said during the handover.
“These motorcycles will help you reach every corner. Be proactive, be professional and make sure no community is left behind.”
The director of health of the council, Martha Kummiap, said the motorcycles would improve the directorate’s ability to conduct regular field visits and trace people who may have been exposed.
“This will change how we work. We can now do daily visits, trace contacts faster and get suspected cases to the health facility before it’s too late,” Ms Kummiap said.
She said the collaboration with the state Ministry of Health had also provided training and supplies to support health workers involved in the outbreak response.
The council said it had commenced radio sensitisation and community outreach to educate residents about diphtheria and measures to reduce transmission.
Diphtheria is a vaccine-preventable bacterial disease that can spread through respiratory droplets and close contact. It can cause serious complications and death when treatment is delayed.
Health authorities have urged parents and caregivers to ensure that children receive routine vaccinations and advised residents to seek medical attention promptly when symptoms such as sore throat, fever or difficulty breathing occur.
Mr Christopher also urged residents to cooperate with health workers during surveillance and contact-tracing activities.
“We are custodians of our communities. If we keep our drainages clean, if we report early, if we support the health teams when they come around, we will defeat this,” he said.
The council said it would continue working with the Plateau State Ministry of Health and other partners to strengthen surveillance and response until the outbreak is contained.
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Long before the gradual withdrawal of international HIV funding exposed the fragility of Nigeria’s HIV response, Akwa Ibom and Rivers states had enacted laws intended to prevent such a crisis.
The laws recognised that donor assistance would not last forever and envisaged a future in which governors provided political leadership, governments financed programmes from domestic resources, local councils coordinated community interventions, and legal protections encouraged people living with HIV to seek treatment without fear of discrimination.
On paper, the laws offered a blueprint for sustainability. However, a PREMIUM TIMES investigation found little publicly available evidence that several of the statutory mechanisms operated as intended during the period under review, even as donor-supported community services began disappearing in both states.
The findings raise a critical question: if institutions specifically created to sustain the HIV response are not fully functional before donors leave, what happens when external funding eventually disappears?
The council that should lead HIV response
In Akwa Ibom, the HIV/AIDS Control Agency Law establishes the State Council on HIV/AIDS as the highest policy-making body responsible for coordinating the state’s HIV response.
Its composition reflects the importance attached to the epidemic. The governor chairs the council, while the deputy governor serves as vice-chairperson. Other members include the Secretary to the State Government, the Head of Service, commissioners from key ministries and the Director-General of the State Agency for the Control of AIDS (SACA).
Governor Umo Eno of Akwa Ibom state (CREDIT: Pastor Umo Eno on X)
Under the law, the council is responsible for providing political leadership, mobilising funding, coordinating partnerships, reviewing implementation of the state’s HIV strategic plan and ensuring that the response remains effective.
The law requires the council to meet at least once every quarter.
Yet, despite repeated requests, the Akwa Ibom government did not provide PREMIUM TIMES with records showing how many statutory meetings were held between January 2023 and June 2026, the resolutions reached at those meetings, or actions taken to prepare the state for declining international donor support.
PREMIUM TIMES also reviewed official governmentwebsites, social media pages,publications, press releases and other publicly available records but found no evidence of quarterly council meetings on HIV during the period.
When asked whether the statutory meetings had taken place, Commissioner for Health Ekem Emmanuel said Governor Umo Eno “holds meetings on HIV/AIDS” but referred questions about the number of meetings and records of deliberations to the State Agency for the Control of AIDS.
The commissioner later said he could not be expected to keep track of such meetings.
“You honestly think I will be keeping count of the meetings? I was not the Commissioner for Health in 2023,” he said.
On 7 July, PREMIUM TIMES sent a detailed 12-point enquiry to the agency’s Programme Manager, Enobong Akpan, seeking records of council meetings, budget releases, implementation of the HIV law and the state’s preparedness for shrinking donor support.
Mr Akpan acknowledged receiving the enquiry and initially promised to respond after returning to Akwa Ibom from an official meeting. Despite repeated reminders, he did not respond to the questions.
Missing grassroots structures
Akwa Ibom’s HIV law extends beyond state-level governance. It establishes Local Action Committees on HIV/AIDS across all 31 local government areas, with council chairpersons expected to lead HIV coordination at the local level.
The committees are designed to mobilise communities, coordinate prevention and treatment activities, strengthen awareness campaigns and receive financial support through local government budgets.
Effectively, they are intended to ensure that the HIV response reaches communities long before patients arrive at hospitals or clinics.
However, interviews conducted by PREMIUM TIMES with officials of the Network of People Living with HIV/AIDS in Nigeria (NEPWHAN) in Akwa Ibom, community advocates and local government stakeholders found no evidence that the committees were actively performing those statutory roles.
“We have tried engaging local governments, particularly in areas with high HIV prevalence, but the response has been poor,” Elizabeth Udo, Akwa Ibom State Coordinator of NEPWHAN, told PREMIUM TIMES.
Elizabeth Udo, Akwa Ibom State Coordinator of NEPWHAN
PREMIUM TIMES also could not independently identify recent HIV interventions directly implemented by any of the state’s 31 local governments under the framework created by the law.
Scrutiny of local government spending is further complicated by the 31 councils’ failure to publish their budgets and other fiscal documents, a practice PREMIUM TIMES previously reportedto violate the state’s fiscal responsibility law.
The situation in Rivers is similarly unclear.
Governor Siminalayi Fubara PHOTO CREDIT:Governor Fubara on X]
The Rivers State Agency for the Control of AIDS Law establishesgovernance structures intended to sustain political commitment, mobilise domestic financing and coordinate the HIV response through a Governor’s Committee on AIDS, a State Council on HIV/AIDS and Local Government Action Committees.
Those institutions were expected to become increasingly important as donor support declined.
However, when PREMIUM TIMES requested records on 7 July showing whether the statutory structures remained functional during the donor transition period, the Rivers State Agency for the Control of AIDS did not respond.
Its Programme Manager, Naaziga Francis, initially indicated that he preferred an in-person interview. But when a PREMIUM TIMES reporter travelled to the agency’s office in Port Harcourt, Mr Francis declined to answer the questions.
“I am just a civil servant. Those questions you have asked will have political consequences,” he said.
PREMIUM TIMES also visited the Rivers State Ministry of Health.Officials explained that the prolonged political crisis in the state meant no commissioner had been appointed, while the permanent secretary had retired.
Repeated telephone calls, text messages and WhatsApp messages sent to the state’s Commissioner for Information, Honour Sirawoo, were not answered before publication.
Law still waiting for assent
Beyond questions about governance and financing, another layer of protection remains incomplete.
Across Nigeria, fear of discrimination continues to discourage some people from testing for HIV, disclosing their status or remaining in treatment.
Although the National HIV and AIDS Anti-Discrimination Actprohibits discrimination against people living with HIV, health experts and human rights advocates argue that state-level laws remain important because they can provide clearer implementation mechanisms, assign responsibilities to local institutions and improve access to redress.
Akwa Ibom has attempted to enact such legislation for years.
The State House of Assembly first passedan HIV Anti-Stigma Bill in 2021. Despite repeated calls for then-Governor Udom Emmanuel to sign it, the bill lapsed after failing to receive gubernatorial assent before the Assembly completed its tenure.
Lawmakers passed the legislation againin September 2024, but nearly two years later, it still awaits the governor’s assent.
For people like Grace, Mercy, Victoria and Peter, whose experiences are at the centre of this investigation, the delay represents more than legislative bureaucracy. They say it prolongs an environment in which people living with HIV continue to experience discrimination in workplaces, families and communities.
Ms Udo said NEPWHAN members continue to report workplace discrimination, family rejection, denial of inheritance and gender-based violence linked to their HIV status.
“The government should urgently assent to the anti-stigma law,” she said.
“We should not continue relying on the United States alone for HIV response while neglecting the legal protections that encourage people to seek treatment without fear.”
Rivers State has yet to enact a similar anti-stigma law, although its annual budgets have included provisions for the legislative process.
According toLawyers Alert, a legal and human rights organisation that provides legal services to vulnerable populations, including people living with HIV, the absence of enforceable state legislation weakens both public health and human rights protections.
Its Legal Adviser, Peace Okesola, said fear of discrimination discourages some people from taking HIV tests, disclosing their status, commencing treatment early or remaining in care.
“The enactment and implementation of HIV anti-stigma laws are not merely legislative exercises; they are essential public health and human rights interventions,” the organisation told PREMIUM TIMES.
Assembly promises oversight
The Chairman of the Akwa Ibom House of Assembly Committee on Health, Moses Essien, told PREMIUM TIMES that the legislature had fulfilled its constitutional responsibility by appropriating funds for the HIV response.
“The House of Assembly has exercised its constitutional power by making adequate financial appropriations in the budget for HIV/AIDS,” he said.
“Release of funds is for the appropriate agency to apply for.”
He said lawmakers had not received any formal report indicating that approved funds were withheld.
Regarding concerns about whether the State Council on HIV/AIDS had met as required by law, Mr Essien said the committee would engage the State Agency for the Control of AIDS later this year.
“We will surely direct adherence to regulations covering the agency,” he said.
On the unsigned HIV Anti-Stigma Bill, Mr Essien, who sponsored the legislation, said he recently reminded Deputy Governor Akon Eyakenyi to bring it to the governor’s attention.
He disagreed with suggestions that the Local Action Committees on HIV/AIDS were inactive.
“I won’t subscribe to the committee’s inactivity because I am aware of steps taken by SACA regarding the functionality of all committees,” he said.
He added that Akwa Ibom had established a Local Resource Mobilisation Committee, headed by former Speaker Sam Ikon, to explore domestic financing options as donor support declines.
“As an Assembly that is concerned with the welfare of our people, we will make more budgetary provisions for HIV/AIDS in the next budget,” he added.
Beyond budgets, behind every statistic
The unanswered questions at the heart of this investigation extend beyond government paperwork.
Why were HIV appropriations identified by PREMIUM TIMES not reflected in available budget implementation records? Have the statutory governance structures established under state laws been operating as required? What concrete measures have Rivers and Akwa Ibom taken to sustain HIV services as donor funding declines? And how will the governments finance community-based interventions that patients and advocates say have disappeared?
For people living with HIV, these are not abstract questions of governance.
They determine whether a missed clinic appointment triggers a follow-up phone call, whether medicines reach patients who are too afraid to be seen at HIV clinics, whether newly diagnosed adolescents find support instead of isolation, and whether decades of progress against one of Nigeria’s most persistent public health challenges can survive a changing funding landscape.
Across the three parts of this investigation, PREMIUM TIMES found a widening gap between the structures established to sustain the HIV response and the experiences of people who depend on them.
Budgets reviewed by PREMIUM TIMES show that funds were appropriated. Laws enacted by both states created institutions intended to provide political leadership, sustainable financing and community coordination. Government officials insist efforts are being made.
Yet critical questions about implementation, accountability and preparedness remain unanswered.
Grace’s family still remembers a woman who fought to preserve her dignity until she believed the system created to protect her had failed her.
Her story, and those of countless others, point to the human cost of that uncertainty. Behind every unaccounted-for appropriation, delayed anti-stigma law and unanswered question about statutory institutions are people whose survival depends not only on antiretroviral medicines, but also on governments fulfilling the responsibilities they have already written into law.
Editor’s Note: *The names marked with asterisks have been changed to protect the privacy and identities of vulnerable individuals featured in this report.
This reporting was supported by the Centre for Journalism Innovation and Development (CJID).
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