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PT Health Watch: How laboratory tests can help detect colorectal cancer early

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Colorectal cancer, which affects the colon and rectum, is one of the most common cancers globally, yet it can remain unnoticed for a long time because some people have no symptoms in the early stages.

The World Health Organisation (WHO) estimates that 1.9 million new cases of colorectal cancer and more than 900,000 deaths occurred globally in 2022.

The agency said symptoms, when they occur, may include blood in the stool, persistent changes in bowel habits, abdominal pain, unexplained weight loss and fatigue.

Because some people may not notice any warning signs, screening can provide an opportunity to identify possible abnormalities before the disease becomes advanced.

What happens before a diagnosis is confirmed?

Laboratory investigations are an important part of that process, as medical laboratory scientists examine samples that can provide clues about what is happening in a patient’s body.

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Speaking with PT HEALTH WATCH, Adedoye David, a medical laboratory scientist, said laboratory testing contributes to the investigation of colorectal cancer through the examination of biological samples, including stool, blood and tissue.

One of the investigations is the Faecal Occult Blood Test (FOBT), which detects blood in stool that may not be visible to the naked eye.

Another is the Faecal Immunochemical Test (FIT), which uses antibodies to detect human haemoglobin in stool.

These tests can help identify people who may require further assessment, but Mr David stressed that detecting blood in stool is not the same as diagnosing cancer.

“Stool-based tests are very important for detecting hidden blood in stool. It could be reliable if the test investigation is carried out using the right and standard operating procedures.

“But as much as it can be reliable in detecting hidden blood, it might not be totally reliable in the diagnosis of colorectal cancer,”he said.

Where further investigation is necessary, Mr David said a patient may be referred for procedures such as colonoscopy, during which abnormal areas can be identified and tissue samples taken for laboratory examination.

A biopsy can then help determine whether the abnormal tissue is cancerous.

Why symptoms should not be ignored

The distinction between screening and diagnosis is important because colorectal cancer does not always announce itself with obvious symptoms.

A person who feels healthy may therefore not consider testing necessary, while another may receive a negative stool test and conclude that further medical attention is unnecessary.

Mr David said both assumptions could be misleading.

He urged people to seek medical advice when they experience persistent symptoms rather than waiting for them to become severe.

He also advised people with a family history of colorectal cancer or long-term inflammatory bowel disease to discuss their risk with healthcare professionals and determine whether they require earlier or more frequent screening.

WHO identifies family history of colorectal cancer and certain inflammatory bowel diseases among factors that can increase a person’s risk of developing the disease.

Although colorectal cancer is more common with increasing age, it is not exclusively a disease of older people. WHO has also reported a rising incidence among younger adults in several countries.

Screening is only useful when people can complete it

The challenge, however, is not simply persuading people to undergo screening. The health system must also be able to support them when a test produces an abnormal result.

Evidence from Nigeria illustrates this point.

A Nigerian community-based study involving more than 2,000 adults found that FIT screening was feasible. However, the researchers also highlighted challenges with follow-up colonoscopy after positive results.

This means that detecting a possible problem is only one part of the process. Patients must be able to access the additional investigations required to establish what the abnormal result means and, where necessary, begin treatment.

Mr David identified limited facilities capable of carrying out some key investigations and the cost of available services as major challenges facing colorectal cancer testing in Nigeria.

For people who may already be hesitant about testing, the cost and availability of diagnostic services can make early detection even more difficult.

READ ALSO: Hot tea, coffee linked to higher risk of oesophageal cancer — Study

Mr David also urged Nigerians to overcome the embarrassment that may come with providing stool samples for laboratory examination.

“There is nothing to be ashamed of producing a stool sample. It is just like any other medical sample and it is needed for us to carry out informed diagnosis,” he said.

Ultimately, a stool test is not a verdict on whether a person has cancer. Rather, it can be one step in a process that helps health professionals decide who may need further investigation.

For Mr David, improving colorectal cancer outcomes therefore requires both public awareness and access to appropriate laboratory and diagnostic services, so that people can seek help early and abnormal findings can be properly investigated.


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Non-communicable diseases caused 74% of global deaths in 2023

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Non-communicable diseases (NCDs) such as heart disease, diabetes and dementia accounted for 74 per cent of global deaths in 2023, up from 58 per cent in 2000, according to the latest estimates released by the World Health Organisation (WHO).

The findings, contained in the WHO’s latest Global Health Estimates released on Friday, show that although global life expectancy has largely recovered from the disruption caused by the COVID-19 pandemic, the world’s disease burden is increasingly shifting towards chronic illnesses and mental health conditions.

According to the report, global life expectancy reached 73.3 years in 2023, almost returning to the 73.4 years recorded in 2019 before the pandemic. However, healthy life expectancy, which measures the number of years people live in good health, recovered more slowly, reaching 62.8 years in 2023, still 0.4 years below its pre-pandemic level.

The WHO noted that eight of the world’s 10 leading causes of death were NCDs in 2023, highlighting a long-term global shift away from communicable diseases.

Cardiovascular diseases remain leading killer

The report identified cardiovascular diseases as the leading cause of death and disease burden worldwide.

It said ischaemic heart disease alone caused approximately 9.5 million deaths and 210 million disability-adjusted life years (DALYs) in 2023. DALYs measure years of healthy life lost due to illness, disability or premature death.

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While many parts of the world have made significant progress in reducing the burden of ischaemic heart disease since 2000, the WHO reported rising individual-level risks in the Western Pacific and South-East Asia regions, highlighting persistent inequalities in cardiovascular health outcomes.

The organisation also reported substantial increases in the burden of other chronic diseases.

According to the report, the risk of dying from diabetes has risen considerably since 2000, particularly in South-East Asia.

Alzheimer’s disease and dementia have also become more prominent.

Dementia rose from the 19th leading cause of death globally in 2000 to the fifth in 2023, while deaths linked to the condition tripled during the period.

Mental health concerns

The WHO also highlighted the growing impact of mental health conditions on global health.

Between 2019 and 2023, the global age-standardised DALY rate increased by approximately 20 per cent for depressive disorders and nearly 45 per cent for anxiety disorders.

Together, depression and anxiety accounted for an estimated 110 million years of healthy life lost through premature death and disability in 2023.

The report further showed changing patterns in drug use disorders across regions.

Between 2000 and 2023, the WHO Region of the Americas recorded the largest increases in mortality risk and healthy life loss associated with drug use disorders, while the Western Pacific region experienced substantial declines.

READ ALSO: Drug-resistant bacterial infections kill one million people annually – WHO

Need for stronger health data systems

Speaking further on the findings, Alani Labrique, Director of WHO’s Department of Data, Digital Health, Analytics and AI, described rising life expectancy as one of public health’s greatest achievements.

However, Mr Labrique noted that the next challenge is ensuring that the additional years people live are spent in good health, while health systems adapt to the changing needs of ageing populations and the growing burden of chronic diseases.

He said the estimates provide countries with evidence on how patterns of death and disease burden are changing over time, helping governments shape health policies, strengthen digital and data infrastructure, and improve their ability to generate insights needed for targeted health interventions.


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PT Health Watch: Can menstrual cups break hymen or affect virginity?

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As more women consider menstrual cups as an option for managing their periods, questions have emerged about whether using them can affect the hymen or a woman’s virginity.

Some people fear that inserting a menstrual cup could “break” the hymen, cause a woman to lose her virginity or permanently make the vagina “loose”.

Speaking with PT Health Watch, Elizabeth Adewale, a Certified Holistic Sex Educator and Public Health Professional, said many of these concerns stem from misconceptions about the hymen and what it means medically to be a virgin.

Hymen changes

According to Ms Adewale, inserting a menstrual cup can stretch the hymen and, in some cases, may cause a small tear, but “this does not mean that a woman has lost her virginity.”

She explained that the hymen is a thin, elastic fold of tissue around the vaginal opening that varies in shape, thickness and elasticity from woman to woman.

“If it were a seal, menstrual blood and normal vaginal discharge wouldn’t be able to come out,” she said.

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Ms Adewale said the hymen can also change for reasons unrelated to sexual intercourse, including physical activities such as cycling, gymnastics and other exercise. She added that some women may have very little hymenal tissue, while in others it may be difficult to see.

The American College of Obstetricians and Gynaecologists (ACOG) also explains that the hymen is a thin membrane that partially covers the entrance to the vagina and can be stretched or torn through tampon use, sports activities or medical procedures. It also says the presence or absence of the hymen does not indicate “virginity”.

Virginity marker

Ms Adewale said the belief that every woman is born with a hymen that remains intact until her first sexual experience is incorrect.

“The hymen is not a virginity marker,” she said.

She explained that the hymen does not simply disappear after sexual intercourse and can still be present afterwards, although its appearance may have changed.

According to the expert, this means that looking at a woman’s hymen cannot establish whether she has had sex.

The World Health Organisation (WHO) says there is no scientific or clinical examination that can prove whether a woman or girl has had vaginal intercourse. It also states that the appearance of the hymen cannot prove whether someone has had sexual intercourse or is sexually active.

Vaginal elasticity

Another concern is that inserting a menstrual cup could permanently stretch the vagina and make it “loose”.

Ms Adewale said there is no medical basis for this belief.

“The vagina is an elastic, muscular canal,” she said, noting that it can relax, expand and contract depending on what is happening.

She said inserting or removing a menstrual cup does not permanently stretch the vagina.

“Your vagina isn’t going to suddenly become a wide-open hole because you’ve used a menstrual cup,” she said.

However, Ms Adewale noted that vaginal insertion can be painful or difficult for some women.

She explained that women with vaginismus, for instance, may experience involuntary tightening of the vaginal or pelvic floor muscles, making the insertion of a menstrual cup, tampon, finger or penis painful or difficult.

“It’s not because their vagina is too small,” she said.

According to ACOG, vaginismus is an involuntary tightening of the muscles at the opening of the vagina that can make penetration painful or difficult.

Using menstral cup

For women who choose to try a menstrual cup, Ms Adewale advised first-time users not to rush the process.

READ ALSO: Group calls for reusable pads as menstrual stigma, access gaps persist

She recommended relaxing before insertion, washing the hands and cleaning the cup properly, finding a comfortable position and following the manufacturer’s instructions on how to fold and insert the cup.

A woman can squat, sit on the toilet or stand with one leg raised on a stool, she said, adding that taking slow, deep breaths can also help.

“Once you’ve successfully inserted it, allow it to open properly and create a seal, but don’t force it. If you experience significant pain, stop, don’t have to force it,” she said.

She added that first-time users may need time to become comfortable with the process and understand what works best for them.

Ms Adewale said the choice of menstrual product is personal and women should not feel pressured to use a menstrual cup if it does not work for them.


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