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PT Health Watch: How laboratory tests can help detect colorectal cancer early

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Colorectal cancer, which affects the colon and rectum, is one of the most common cancers globally, yet it can remain unnoticed for a long time because some people have no symptoms in the early stages.

The World Health Organisation (WHO) estimates that 1.9 million new cases of colorectal cancer and more than 900,000 deaths occurred globally in 2022.

The agency said symptoms, when they occur, may include blood in the stool, persistent changes in bowel habits, abdominal pain, unexplained weight loss and fatigue.

Because some people may not notice any warning signs, screening can provide an opportunity to identify possible abnormalities before the disease becomes advanced.

What happens before a diagnosis is confirmed?

Laboratory investigations are an important part of that process, as medical laboratory scientists examine samples that can provide clues about what is happening in a patient’s body.

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Speaking with PT HEALTH WATCH, Adedoye David, a medical laboratory scientist, said laboratory testing contributes to the investigation of colorectal cancer through the examination of biological samples, including stool, blood and tissue.

One of the investigations is the Faecal Occult Blood Test (FOBT), which detects blood in stool that may not be visible to the naked eye.

Another is the Faecal Immunochemical Test (FIT), which uses antibodies to detect human haemoglobin in stool.

These tests can help identify people who may require further assessment, but Mr David stressed that detecting blood in stool is not the same as diagnosing cancer.

“Stool-based tests are very important for detecting hidden blood in stool. It could be reliable if the test investigation is carried out using the right and standard operating procedures.

“But as much as it can be reliable in detecting hidden blood, it might not be totally reliable in the diagnosis of colorectal cancer,”he said.

Where further investigation is necessary, Mr David said a patient may be referred for procedures such as colonoscopy, during which abnormal areas can be identified and tissue samples taken for laboratory examination.

A biopsy can then help determine whether the abnormal tissue is cancerous.

Why symptoms should not be ignored

The distinction between screening and diagnosis is important because colorectal cancer does not always announce itself with obvious symptoms.

A person who feels healthy may therefore not consider testing necessary, while another may receive a negative stool test and conclude that further medical attention is unnecessary.

Mr David said both assumptions could be misleading.

He urged people to seek medical advice when they experience persistent symptoms rather than waiting for them to become severe.

He also advised people with a family history of colorectal cancer or long-term inflammatory bowel disease to discuss their risk with healthcare professionals and determine whether they require earlier or more frequent screening.

WHO identifies family history of colorectal cancer and certain inflammatory bowel diseases among factors that can increase a person’s risk of developing the disease.

Although colorectal cancer is more common with increasing age, it is not exclusively a disease of older people. WHO has also reported a rising incidence among younger adults in several countries.

Screening is only useful when people can complete it

The challenge, however, is not simply persuading people to undergo screening. The health system must also be able to support them when a test produces an abnormal result.

Evidence from Nigeria illustrates this point.

A Nigerian community-based study involving more than 2,000 adults found that FIT screening was feasible. However, the researchers also highlighted challenges with follow-up colonoscopy after positive results.

This means that detecting a possible problem is only one part of the process. Patients must be able to access the additional investigations required to establish what the abnormal result means and, where necessary, begin treatment.

Mr David identified limited facilities capable of carrying out some key investigations and the cost of available services as major challenges facing colorectal cancer testing in Nigeria.

For people who may already be hesitant about testing, the cost and availability of diagnostic services can make early detection even more difficult.

READ ALSO: Hot tea, coffee linked to higher risk of oesophageal cancer — Study

Mr David also urged Nigerians to overcome the embarrassment that may come with providing stool samples for laboratory examination.

“There is nothing to be ashamed of producing a stool sample. It is just like any other medical sample and it is needed for us to carry out informed diagnosis,” he said.

Ultimately, a stool test is not a verdict on whether a person has cancer. Rather, it can be one step in a process that helps health professionals decide who may need further investigation.

For Mr David, improving colorectal cancer outcomes therefore requires both public awareness and access to appropriate laboratory and diagnostic services, so that people can seek help early and abnormal findings can be properly investigated.


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Health

North accounts for most of Nigeria’s recorded maternal deaths – Report

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Women in northern Nigeria continue to bear a disproportionate burden of maternal deaths, with the Northwest and Northeast geopolitical zones accounting for about three-quarters of reported fatalities in health facilities, according to the 2026 Joint Annual Review (JAR) Statistical Book.

The report also highlights significant disparities in maternal health outcomes between rural and urban areas, with rural women recording a maternal mortality ratio of 656 deaths per 100,000 live births, compared with 444 deaths per 100,000 live births in urban areas.

Produced by the Federal Ministry of Health and Social Welfare, the report reviews the third year of implementation of the Health Sector Strategic Blueprint. It was presented at the third Nigeria Health Sector Joint Annual Review in Abuja on 10 November.

The findings highlight persistent inequalities in maternal healthcare access and outcomes, despite a reported decline in maternal deaths across health facilities nationally.

According to the report, Nigeria recorded thousands of maternal deaths in health facilities between January and September 2026, although the figures represent only deaths captured by the facility reporting system.

The ministry acknowledged that the figures could be underreported or overreported but described the data as reliable for monitoring trends in the health sector.

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Maternal mortality remains high

Maternal mortality refers to the death of a woman during pregnancy, childbirth or within 42 days of the termination of pregnancy from causes related to or aggravated by the pregnancy or its management.

Most maternal deaths are preventable through timely access to quality antenatal care, skilled birth attendance, emergency obstetric services and appropriate postnatal care.

Despite the reported improvements, Nigeria’s maternal mortality ratio remains a major public health concern.

The JAR Statistical Book puts the country’s maternal mortality ratio at 572 deaths per 100,000 live births, significantly above the Sustainable Development Goal (SDG) target of fewer than 70 deaths per 100,000 live births by 2030.

The burden is particularly concerning given Nigeria’s contribution to global maternal deaths.

In its 2023 report, titled “Improving Maternal and Newborn Health and Survival and Reducing Stillbirths: Progress Report 2023”, the World Health Organisation (WHO) estimated that Nigeria recorded 82,000 maternal deaths, 181,000 stillbirths and 277,000 neonatal deaths in 2020.

The combined 540,000 deaths accounted for 12 per cent of global maternal, stillbirth and neonatal deaths, despite Nigeria contributing only six per cent of global live births.

The report ranked Nigeria second after India among countries with the highest combined burden of maternal deaths, stillbirths and neonatal deaths.

Reported maternal deaths decline

The JAR data indicate a downward trend in facility-reported maternal deaths over the review period.

The country recorded 5,391 maternal deaths in health facilities in 2024, compared with 4,455 in 2025.

The figure declined further in 2026, although the exact total requires confirmation against the final statistical table. The quarterly data also indicate improvements.

Following a peak in the second quarter of 2024, maternal deaths and the maternal mortality ratio generally declined. By the third quarter of 2026, the maternal mortality ratio had fallen to 128 deaths per 100,000 live births, representing a reduction of about 46 per cent from the earlier peak.

Maternal deaths during the same period also declined by approximately 40 per cent to 947.

However, these improvements have not been evenly distributed across the country.

Northern states bear the burden

According to the report, maternal deaths over the past three years were heavily concentrated in the Northwest and Northeast geopolitical zones.

By 2026, the two zones together accounted for approximately three-quarters of all documented maternal deaths in health facilities.

The five northern states with the highest maternal mortality burden were Kano, Borno, Jigawa, Yobe and Katsina.

While the national figures showed a downward trend, maternal deaths reportedly increased across the two northern zones, contrasting with reductions recorded in southern parts of the country.

ALSO READ: Faith leaders urged to confront beliefs, family decisions driving maternal deaths in Kano

In most southern states, fewer than 50 maternal deaths were reported. The states with the lowest recorded numbers included Osun (four deaths), Abia (five), Enugu (eight), Ekiti (nine), and Bayelsa (nine).

Maternal morbidity

Beyond deaths, the report also highlights the burden of maternal morbidity, including complications that can have lasting effects on women’s health, wellbeing and livelihoods. In 2026, approximately 3,060 women were diagnosed with vesicovaginal fistula (VVF), compared with 4,350 in 2025.

VVF is an abnormal opening between the bladder and vagina that can result in continuous, involuntary leakage of urine, often following prolonged or obstructed labour.

Of the women diagnosed in 2026, 1,737 underwent surgical repair, representing 56.8 per cent of those diagnosed. This was lower than in 2025, when 2,564 women (59 per cent) underwent repairs.

The Northwest and Northeast again recorded the highest burden, with 1,420 and 982 cases, respectively, in 2026. The figures underscore the need to strengthen access to emergency obstetric care, timely referrals and surgical treatment, particularly in underserved communities.


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Ebola: Swiss woman evacuated from Nigeria discharged after recovery

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The woman who tested positive for Ebola in Nigeria and was evacuated to Switzerland for treatment has been discharged from hospital after making a full recovery.

She was discharged from Geneva University Hospitals on Wednesday, after medical personnel confirmed her recovery, Reuters reported on Thursday, quoting a statement from the hospital.

“After the medical team confirmed her full recovery, the cantonal physician authorised the patient being treated for Ebola virus disease to leave the Geneva University Hospitals (HUG) on 11 November 2026,” the hospital said.

The Uganda-born woman and her husband, a Swiss diplomat, were evacuated from Nigeria to Switzerland on 26 October. Her evacuation was confirmed by the Minister of Health and Social Welfare, Muhammad Pate.

The patient had returned to Abuja from Uganda on 3 October. She developed symptoms days later and was admitted to a private health facility before the Nigeria Centre for Disease Control and Prevention (NCDC) was notified. Laboratory tests confirmed the infection on 20 October.

Nigeria continues Ebola surveillance

The NCDC’s latest Ebola situation dashboard, updated on 12 November with data as of 11 November, lists one confirmed case, no deaths and seven negative cases.

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It also shows that 62 contacts linked to the confirmed case have been identified. Of these, 52 have completed their mandatory 21-day follow-up, while 10 remain under monitoring.

The NCDC said its response includes contact tracing, investigation of reported alerts, laboratory testing, infection prevention and control measures, and surveillance at the country’s points of entry.

On 11 November, NCDC disclosed that Nigeria recorded no additional confirmed Ebola cases since the imported infection was confirmed.

The agency has urged healthcare workers to remain vigilant, ask patients about their travel and exposure histories, and promptly report suspected cases to public health authorities.

READ ALSO: Ebola: Nigeria records no new cases 21 days after imported infection – NCDC

Regional outbreak continues

The situation in Nigeria is part of a wider outbreak of Bundibugyo virus disease affecting parts of Africa.

In its latest situation update published on 6 November, the World Health Organisation (WHO) said the DRC had recorded 10,668 confirmed cases and 5,198 deaths as of 3 November, across 67 health zones in eight provinces.

Kenya had recorded nine confirmed cases and two deaths, while Nigeria had reported one imported case. WHO said there had been no new confirmed cases in Kenya or Nigeria since its previous update.


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